Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study

Objective:Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will therefore contaminate breast milk. The European Food Safety Authority has set a limit for temporary tolerable daily intake of 4 μg/kg body weight/day in breastfeeding...

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Autores principales:	Seda Çiftçi, Sıddıka Songül Yalçın, Gülhan Samur
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayincilik 2021
Materias:	bisphenol a breastfeeding exposure lactation maternal exposure Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/1d2c6233de2249848a36a11384d79f1e
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spelling	oai:doaj.org-article:1d2c6233de2249848a36a11384d79f1e2021-11-26T06:10:16ZBisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study1308-57271308-573510.4274/jcrpe.galenos.2020.2021.0305https://doaj.org/article/1d2c6233de2249848a36a11384d79f1e2021-12-01T00:00:00Z http://www.jcrpe.org/archives/archive-detail/article-preview/bisphenol-a-exposure-in-exclusively-breastfed-nfan/46958 https://doaj.org/toc/1308-5727https://doaj.org/toc/1308-5735Objective:Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will therefore contaminate breast milk. The European Food Safety Authority has set a limit for temporary tolerable daily intake of 4 μg/kg body weight/day in breastfeeding infants. The aim of this study was to measure human milk BPA concentrations in Turkish women and thus exclusively breastfed infants’ exposure to BPA.Methods:Healthy, postnatal, exclusively breastfeeding women were recruited and breast milk samples were collected. Free BPA concentration was analyzed in the milk samples using competitive enzyme-linked immunosorbent assay. Participants’ demographic characteristics and nutritional habits were investigated through face-to-face interviews using a detailed questionnaire.Results:Eighty women participated. Median milk free BPA level was 0.63 μg/L. There was no statistically significant association between maternal body mass index, birth type, parity, infant birth week, infant birth weight, and human milk BPA concentration. Nevertheless, there was a significant association between human milk BPA level and consumption of fast-food and carbonated drinks (p=0.022 and p=0.018, respectively). Exclusively breastfed infants’ mean BPA exposure was 0.0099±0.0079 μg/kg bw/day. There was a moderate negative significant correlation between infant BPA exposure and infant current body weight (r=0.327, p=0.003).Conclusion:BPA exposure in exclusively breastfed infants was within accepted limits and the current dietary exposure level of infants in this cohort was safe.Seda ÇiftçiSıddıka Songül YalçınGülhan SamurGalenos Yayincilikarticlebisphenol abreastfeedingexposurelactationmaternal exposurePediatricsRJ1-570Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENJCRPE, Vol 13, Iss 4, Pp 375-383 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bisphenol a breastfeeding exposure lactation maternal exposure Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	bisphenol a breastfeeding exposure lactation maternal exposure Pediatrics RJ1-570 Diseases of the endocrine glands. Clinical endocrinology RC648-665 Seda Çiftçi Sıddıka Songül Yalçın Gülhan Samur Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
description	Objective:Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will therefore contaminate breast milk. The European Food Safety Authority has set a limit for temporary tolerable daily intake of 4 μg/kg body weight/day in breastfeeding infants. The aim of this study was to measure human milk BPA concentrations in Turkish women and thus exclusively breastfed infants’ exposure to BPA.Methods:Healthy, postnatal, exclusively breastfeeding women were recruited and breast milk samples were collected. Free BPA concentration was analyzed in the milk samples using competitive enzyme-linked immunosorbent assay. Participants’ demographic characteristics and nutritional habits were investigated through face-to-face interviews using a detailed questionnaire.Results:Eighty women participated. Median milk free BPA level was 0.63 μg/L. There was no statistically significant association between maternal body mass index, birth type, parity, infant birth week, infant birth weight, and human milk BPA concentration. Nevertheless, there was a significant association between human milk BPA level and consumption of fast-food and carbonated drinks (p=0.022 and p=0.018, respectively). Exclusively breastfed infants’ mean BPA exposure was 0.0099±0.0079 μg/kg bw/day. There was a moderate negative significant correlation between infant BPA exposure and infant current body weight (r=0.327, p=0.003).Conclusion:BPA exposure in exclusively breastfed infants was within accepted limits and the current dietary exposure level of infants in this cohort was safe.
format	article
author	Seda Çiftçi Sıddıka Songül Yalçın Gülhan Samur
author_facet	Seda Çiftçi Sıddıka Songül Yalçın Gülhan Samur
author_sort	Seda Çiftçi
title	Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
title_short	Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
title_full	Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
title_fullStr	Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
title_full_unstemmed	Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study
title_sort	bisphenol a exposure in exclusively breastfed infants and lactating women: an observational cross-sectional study
publisher	Galenos Yayincilik
publishDate	2021
url	https://doaj.org/article/1d2c6233de2249848a36a11384d79f1e
work_keys_str_mv	AT sedaciftci bisphenolaexposureinexclusivelybreastfedinfantsandlactatingwomenanobservationalcrosssectionalstudy AT sıddıkasongulyalcın bisphenolaexposureinexclusivelybreastfedinfantsandlactatingwomenanobservationalcrosssectionalstudy AT gulhansamur bisphenolaexposureinexclusivelybreastfedinfantsandlactatingwomenanobservationalcrosssectionalstudy
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Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study

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