Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredoxin interacting protein (TXNIP), and attenuates in...

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Autores principales:	Chad N. Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A. Bonzo, Moshe Levi, David J. Waxman, Frank J. Gonzalez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa
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spelling	oai:doaj.org-article:1d2f0c30e94149ecae45a0d442e06efa2021-12-02T15:39:25ZLong non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting10.1038/s41467-020-19554-72041-1723https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19554-7https://doaj.org/toc/2041-1723PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredoxin interacting protein (TXNIP), and attenuates inflammasome activation.Chad N. BrockerDonghwan KimTisha MeliaKritika KarriThomas J. VelenosiShogo TakahashiDaisuke AibaraJessica A. BonzoMoshe LeviDavid J. WaxmanFrank J. GonzalezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chad N. Brocker Donghwan Kim Tisha Melia Kritika Karri Thomas J. Velenosi Shogo Takahashi Daisuke Aibara Jessica A. Bonzo Moshe Levi David J. Waxman Frank J. Gonzalez Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
description	PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredoxin interacting protein (TXNIP), and attenuates inflammasome activation.
format	article
author	Chad N. Brocker Donghwan Kim Tisha Melia Kritika Karri Thomas J. Velenosi Shogo Takahashi Daisuke Aibara Jessica A. Bonzo Moshe Levi David J. Waxman Frank J. Gonzalez
author_facet	Chad N. Brocker Donghwan Kim Tisha Melia Kritika Karri Thomas J. Velenosi Shogo Takahashi Daisuke Aibara Jessica A. Bonzo Moshe Levi David J. Waxman Frank J. Gonzalez
author_sort	Chad N. Brocker
title	Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
title_short	Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
title_full	Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
title_fullStr	Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
title_full_unstemmed	Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
title_sort	long non-coding rna gm15441 attenuates hepatic inflammasome activation in response to ppara agonism and fasting
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa
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Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting

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