Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during fasting in the liver. Here the authors show that Gm15441 is a PPAR-alpha dependent lncRNA that prevents the expression of its antisense transcript, thioredoxin interacting protein (TXNIP), and attenuates in...
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Autores principales: | Chad N. Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A. Bonzo, Moshe Levi, David J. Waxman, Frank J. Gonzalez |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/1d2f0c30e94149ecae45a0d442e06efa |
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