Lipidome determinants of maximal lifespan in mammals
Abstract Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid c...
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Nature Portfolio
2017
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oai:doaj.org-article:1d2f7257382a4f6e9f237b66319e72e42021-12-02T12:32:41ZLipidome determinants of maximal lifespan in mammals10.1038/s41598-017-00037-72045-2322https://doaj.org/article/1d2f7257382a4f6e9f237b66319e72e42017-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00037-7https://doaj.org/toc/2045-2322Abstract Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals.Katarzyna BozekEkaterina E. KhrameevaJane ReznickDamir OmerbašićNigel C. BennettGary R. LewinJorge AzpuruaVera GorbunovaAndrei SeluanovPierrick RegnardFanelie WanertJulia MarchalFabien PifferiFabienne AujardZhen LiuPeng ShiSvante PääboFlorian SchroederLothar WillmitzerPatrick GiavaliscoPhilipp KhaitovichNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Katarzyna Bozek Ekaterina E. Khrameeva Jane Reznick Damir Omerbašić Nigel C. Bennett Gary R. Lewin Jorge Azpurua Vera Gorbunova Andrei Seluanov Pierrick Regnard Fanelie Wanert Julia Marchal Fabien Pifferi Fabienne Aujard Zhen Liu Peng Shi Svante Pääbo Florian Schroeder Lothar Willmitzer Patrick Giavalisco Philipp Khaitovich Lipidome determinants of maximal lifespan in mammals |
| description |
Abstract Maximal lifespan of mammalian species, even if closely related, may differ more than 10-fold, however the nature of the mechanisms that determine this variability is unresolved. Here, we assess the relationship between maximal lifespan duration and concentrations of more than 20,000 lipid compounds, measured in 669 tissue samples from 6 tissues of 35 species representing three mammalian clades: primates, rodents and bats. We identify lipids associated with species’ longevity across the three clades, uncoupled from other parameters, such as basal metabolic rate, body size, or body temperature. These lipids clustered in specific lipid classes and pathways, and enzymes linked to them display signatures of greater stabilizing selection in long-living species, and cluster in functional groups related to signaling and protein-modification processes. These findings point towards the existence of defined molecular mechanisms underlying variation in maximal lifespan among mammals. |
| format |
article |
| author |
Katarzyna Bozek Ekaterina E. Khrameeva Jane Reznick Damir Omerbašić Nigel C. Bennett Gary R. Lewin Jorge Azpurua Vera Gorbunova Andrei Seluanov Pierrick Regnard Fanelie Wanert Julia Marchal Fabien Pifferi Fabienne Aujard Zhen Liu Peng Shi Svante Pääbo Florian Schroeder Lothar Willmitzer Patrick Giavalisco Philipp Khaitovich |
| author_facet |
Katarzyna Bozek Ekaterina E. Khrameeva Jane Reznick Damir Omerbašić Nigel C. Bennett Gary R. Lewin Jorge Azpurua Vera Gorbunova Andrei Seluanov Pierrick Regnard Fanelie Wanert Julia Marchal Fabien Pifferi Fabienne Aujard Zhen Liu Peng Shi Svante Pääbo Florian Schroeder Lothar Willmitzer Patrick Giavalisco Philipp Khaitovich |
| author_sort |
Katarzyna Bozek |
| title |
Lipidome determinants of maximal lifespan in mammals |
| title_short |
Lipidome determinants of maximal lifespan in mammals |
| title_full |
Lipidome determinants of maximal lifespan in mammals |
| title_fullStr |
Lipidome determinants of maximal lifespan in mammals |
| title_full_unstemmed |
Lipidome determinants of maximal lifespan in mammals |
| title_sort |
lipidome determinants of maximal lifespan in mammals |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/1d2f7257382a4f6e9f237b66319e72e4 |
| work_keys_str_mv |
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