New observations on maternal age effect on germline de novo mutations

The study of germline mutations has been greatly enhanced by massive parallel sequencing technologies. Here the authors use deep sequencing data from nearly 700 parent-child trios to show maternal age has a small but significant correlation with the number of de novomutations in the offspring.

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Autores principales:	Wendy S. W. Wong, Benjamin D. Solomon, Dale L. Bodian, Prachi Kothiyal, Greg Eley, Kathi C. Huddleston, Robin Baker, Dzung C. Thach, Ramaswamy K. Iyer, Joseph G. Vockley, John E. Niederhuber
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d2fddf6abe04f2888ec30cf8d40ace3
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spelling	oai:doaj.org-article:1d2fddf6abe04f2888ec30cf8d40ace32021-12-02T14:38:33ZNew observations on maternal age effect on germline de novo mutations10.1038/ncomms104862041-1723https://doaj.org/article/1d2fddf6abe04f2888ec30cf8d40ace32016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10486https://doaj.org/toc/2041-1723The study of germline mutations has been greatly enhanced by massive parallel sequencing technologies. Here the authors use deep sequencing data from nearly 700 parent-child trios to show maternal age has a small but significant correlation with the number of de novomutations in the offspring.Wendy S. W. WongBenjamin D. SolomonDale L. BodianPrachi KothiyalGreg EleyKathi C. HuddlestonRobin BakerDzung C. ThachRamaswamy K. IyerJoseph G. VockleyJohn E. NiederhuberNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wendy S. W. Wong Benjamin D. Solomon Dale L. Bodian Prachi Kothiyal Greg Eley Kathi C. Huddleston Robin Baker Dzung C. Thach Ramaswamy K. Iyer Joseph G. Vockley John E. Niederhuber New observations on maternal age effect on germline de novo mutations
description	The study of germline mutations has been greatly enhanced by massive parallel sequencing technologies. Here the authors use deep sequencing data from nearly 700 parent-child trios to show maternal age has a small but significant correlation with the number of de novomutations in the offspring.
format	article
author	Wendy S. W. Wong Benjamin D. Solomon Dale L. Bodian Prachi Kothiyal Greg Eley Kathi C. Huddleston Robin Baker Dzung C. Thach Ramaswamy K. Iyer Joseph G. Vockley John E. Niederhuber
author_facet	Wendy S. W. Wong Benjamin D. Solomon Dale L. Bodian Prachi Kothiyal Greg Eley Kathi C. Huddleston Robin Baker Dzung C. Thach Ramaswamy K. Iyer Joseph G. Vockley John E. Niederhuber
author_sort	Wendy S. W. Wong
title	New observations on maternal age effect on germline de novo mutations
title_short	New observations on maternal age effect on germline de novo mutations
title_full	New observations on maternal age effect on germline de novo mutations
title_fullStr	New observations on maternal age effect on germline de novo mutations
title_full_unstemmed	New observations on maternal age effect on germline de novo mutations
title_sort	new observations on maternal age effect on germline de novo mutations
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1d2fddf6abe04f2888ec30cf8d40ace3
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New observations on maternal age effect on germline de novo mutations

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