Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021

Porcine circovirus-like virus (PCLV) is a type of circular <i>Rep</i>-encoding single-stranded DNA virus and may be associated with the development of diarrheal symptoms in pigs. In this study, we retrospectively analyzed three years of past cases in Anhui, China, and reported a case of...

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Autores principales:	Kankan Yang, Menghuan Zhang, Qi Liu, Yingli Cao, Wuyin Zhang, Yueqiao Liang, Xiangjun Song, Kaiyuan Ji, Ying Shao, Kezong Qi, Jian Tu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	porcine circovirus-like virus pregnant sows recombination selection pressure central China Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1d34662ca371423aac5471dc80963834
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spelling	oai:doaj.org-article:1d34662ca371423aac5471dc809638342021-11-25T19:14:10ZEpidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 202110.3390/v131122821999-4915https://doaj.org/article/1d34662ca371423aac5471dc809638342021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2282https://doaj.org/toc/1999-4915Porcine circovirus-like virus (PCLV) is a type of circular <i>Rep</i>-encoding single-stranded DNA virus and may be associated with the development of diarrheal symptoms in pigs. In this study, we retrospectively analyzed three years of past cases in Anhui, China, and reported a case of hemorrhagic enteritis and death in a pregnant sow possibly caused by PCLV. In addition, we analyzed the evolutionary characteristics of PCLV and found that mutation, recombination and selective pressure all played an important role in the evolution of PCLV. We identified N15D and T17S as well as L56T, T58R, K59Q, M62R, L75I and R190K mutations in two different branches, and we noted recombination events in the <i>Rep</i> of a group of Chinese strains. Analysis of selection pressure revealed that PCLV gained more positive selection, indicating that the virus is in a continuous evolutionary state. The PR2 plot, ENC-plot and neutrality analysis showed a greater role of natural selection than that of mutational pressure in the formation of codon usage patterns. This study is the first to identify PCLV in sows with hemorrhagic dysentery and death, and it provides new epidemiological information on PCLV infection in pigs in China.Kankan YangMenghuan ZhangQi LiuYingli CaoWuyin ZhangYueqiao LiangXiangjun SongKaiyuan JiYing ShaoKezong QiJian TuMDPI AGarticleporcine circovirus-like viruspregnant sowsrecombinationselection pressurecentral ChinaMicrobiologyQR1-502ENViruses, Vol 13, Iss 2282, p 2282 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	porcine circovirus-like virus pregnant sows recombination selection pressure central China Microbiology QR1-502
spellingShingle	porcine circovirus-like virus pregnant sows recombination selection pressure central China Microbiology QR1-502 Kankan Yang Menghuan Zhang Qi Liu Yingli Cao Wuyin Zhang Yueqiao Liang Xiangjun Song Kaiyuan Ji Ying Shao Kezong Qi Jian Tu Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021
description	Porcine circovirus-like virus (PCLV) is a type of circular <i>Rep</i>-encoding single-stranded DNA virus and may be associated with the development of diarrheal symptoms in pigs. In this study, we retrospectively analyzed three years of past cases in Anhui, China, and reported a case of hemorrhagic enteritis and death in a pregnant sow possibly caused by PCLV. In addition, we analyzed the evolutionary characteristics of PCLV and found that mutation, recombination and selective pressure all played an important role in the evolution of PCLV. We identified N15D and T17S as well as L56T, T58R, K59Q, M62R, L75I and R190K mutations in two different branches, and we noted recombination events in the <i>Rep</i> of a group of Chinese strains. Analysis of selection pressure revealed that PCLV gained more positive selection, indicating that the virus is in a continuous evolutionary state. The PR2 plot, ENC-plot and neutrality analysis showed a greater role of natural selection than that of mutational pressure in the formation of codon usage patterns. This study is the first to identify PCLV in sows with hemorrhagic dysentery and death, and it provides new epidemiological information on PCLV infection in pigs in China.
format	article
author	Kankan Yang Menghuan Zhang Qi Liu Yingli Cao Wuyin Zhang Yueqiao Liang Xiangjun Song Kaiyuan Ji Ying Shao Kezong Qi Jian Tu
author_facet	Kankan Yang Menghuan Zhang Qi Liu Yingli Cao Wuyin Zhang Yueqiao Liang Xiangjun Song Kaiyuan Ji Ying Shao Kezong Qi Jian Tu
author_sort	Kankan Yang
title	Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021
title_short	Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021
title_full	Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021
title_fullStr	Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021
title_full_unstemmed	Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021
title_sort	epidemiology and evolution of emerging porcine circovirus-like viruses in pigs with hemorrhagic dysentery and diarrhea symptoms in central china from 2018 to 2021
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1d34662ca371423aac5471dc80963834
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Epidemiology and Evolution of Emerging Porcine Circovirus-like Viruses in Pigs with Hemorrhagic Dysentery and Diarrhea Symptoms in Central China from 2018 to 2021

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