Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol
A simple sensitive spectrophotometric method has been suggested for the estimation of pure p-aminophenol(p-AMPL), and p-AMPL results from the hydrolysis of paracetamol(PARL). The suggested method is based on oxidative coupling reaction of p-AMPL with 4-chlororesorcinol (4-CLRL) and potassium perioda...
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College of Education for Pure Sciences
2021
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oai:doaj.org-article:1d35a4c73116410dbaf142657f3c41e22021-12-01T14:54:26ZSpectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol1812-125X2664-253010.33899/edusj.2021.131045.1186https://doaj.org/article/1d35a4c73116410dbaf142657f3c41e22021-12-01T00:00:00Zhttps://edusj.mosuljournals.com/article_169667_eb52268c63e9bd13e70bf2b742319b40.pdfhttps://doaj.org/toc/1812-125Xhttps://doaj.org/toc/2664-2530A simple sensitive spectrophotometric method has been suggested for the estimation of pure p-aminophenol(p-AMPL), and p-AMPL results from the hydrolysis of paracetamol(PARL). The suggested method is based on oxidative coupling reaction of p-AMPL with 4-chlororesorcinol (4-CLRL) and potassium periodate to produce a stable, and water-soluble coloured product with maximum absorption at wavelength 556 nm. Beer's law is followed over the range of concentration from 2 to 20 µg p-AMPL. ml-1. The molar absorptivity value is equal to 1.0277×104 l.mol-1cm-1. All factors responsible for the completed reaction and highest intensity of the product have been studied, and the optimal of each factor has been selected. The suggested method was applied in an indirect method for the<br /> determination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL. The common excipients added did not interfere in the estimation of paracetamol.<br /> The suggested method was applied in an indirect method for the<br /> determination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL. The common excipients added did not interfere in the estimation of paracetamol.Hiba AlhafidNabeel OtmanCollege of Education for Pure Sciencesarticlep-aminophenol,,,،,؛oxidative coupling reaction,,,،,؛4-chlororesorcinol,,,،,؛potassium periodate,,,،,؛paracetamolEducationLScience (General)Q1-390ARENمجلة التربية والعلم, Vol 30, Iss 5, Pp 136-146 (2021) |
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DOAJ |
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DOAJ |
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AR EN |
| topic |
p-aminophenol,, ,،,؛oxidative coupling reaction,, ,،,؛4-chlororesorcinol,, ,،,؛potassium periodate,, ,،,؛paracetamol Education L Science (General) Q1-390 |
| spellingShingle |
p-aminophenol,, ,،,؛oxidative coupling reaction,, ,،,؛4-chlororesorcinol,, ,،,؛potassium periodate,, ,،,؛paracetamol Education L Science (General) Q1-390 Hiba Alhafid Nabeel Otman Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol |
| description |
A simple sensitive spectrophotometric method has been suggested for the estimation of pure p-aminophenol(p-AMPL), and p-AMPL results from the hydrolysis of paracetamol(PARL). The suggested method is based on oxidative coupling reaction of p-AMPL with 4-chlororesorcinol (4-CLRL) and potassium periodate to produce a stable, and water-soluble coloured product with maximum absorption at wavelength 556 nm. Beer's law is followed over the range of concentration from 2 to 20 µg p-AMPL. ml-1. The molar absorptivity value is equal to 1.0277×104 l.mol-1cm-1. All factors responsible for the completed reaction and highest intensity of the product have been studied, and the optimal of each factor has been selected. The suggested method was applied in an indirect method for the<br /> determination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL. The common excipients added did not interfere in the estimation of paracetamol.<br /> The suggested method was applied in an indirect method for the<br /> determination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL. The common excipients added did not interfere in the estimation of paracetamol. |
| format |
article |
| author |
Hiba Alhafid Nabeel Otman |
| author_facet |
Hiba Alhafid Nabeel Otman |
| author_sort |
Hiba Alhafid |
| title |
Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol |
| title_short |
Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol |
| title_full |
Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol |
| title_fullStr |
Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol |
| title_full_unstemmed |
Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol |
| title_sort |
spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –application to paracetamol |
| publisher |
College of Education for Pure Sciences |
| publishDate |
2021 |
| url |
https://doaj.org/article/1d35a4c73116410dbaf142657f3c41e2 |
| work_keys_str_mv |
AT hibaalhafid spectrophotometricestimationofparaaminophenolviaoxidativecouplingreactionwith4chlororesorcinolapplicationtoparacetamol AT nabeelotman spectrophotometricestimationofparaaminophenolviaoxidativecouplingreactionwith4chlororesorcinolapplicationtoparacetamol |
| _version_ |
1718404857607487488 |