Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network

Yu-Chen Chen,1,2 Huiyou Chen,2 Fan Bo,2 Jin-Jing Xu,3 Yi Deng,3 Han Lv,4 Yuexin Cai,5 Wenqing Xia,6 Xindao Yin,2 Jian-Ping Gu,2 Guangming Lu1 1Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China; 2Department of Radiology, Nanjing First Hospital, N...

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Autores principales:	Chen YC, Chen H, Bo F, Xu JJ, Deng Y, Lv H, Cai Y, Xia W, Yin X, Gu JP, Lu GM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	tinnitus anterior cingulate cortex posterior cingulate cortex default mode network resting-state fMRI. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1d360a1a154f443d9ae21cf42a995891
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spelling	oai:doaj.org-article:1d360a1a154f443d9ae21cf42a9958912021-12-02T00:33:00ZTinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network1178-2021https://doaj.org/article/1d360a1a154f443d9ae21cf42a9958912018-08-01T00:00:00Zhttps://www.dovepress.com/tinnitus-distress-is-associated-with-enhanced-resting-state-functional-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yu-Chen Chen,1,2 Huiyou Chen,2 Fan Bo,2 Jin-Jing Xu,3 Yi Deng,3 Han Lv,4 Yuexin Cai,5 Wenqing Xia,6 Xindao Yin,2 Jian-Ping Gu,2 Guangming Lu1 1Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China; 2Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; 3Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; 4Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; 5Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; 6Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Purpose: The default mode network (DMN) has been confirmed to be involved in chronic tinnitus perception. Tinnitus distress may be associated with abnormal functional connectivity (FC) within the DMN regions. The goal of this study was to determine whether tinnitus disrupted the FC patterns within the DMN as measured by using resting-state functional magnetic resonance imaging approach. Patients and methods: Resting-state functional magnetic resonance imaging scans were acquired from 40 chronic bilateral tinnitus patients and 41 healthy controls. Both were age, sex, and education well-matched with normal hearing. Two important DMN regions, the anterior cingulate cortex and posterior cingulate cortex, were chosen as seed regions to detect the FC patterns within the DMN and then determine whether these changes were linked to clinical measures of tinnitus such as tinnitus duration and tinnitus severity. Results: Compared with healthy controls, chronic tinnitus patients manifested significantly enhanced FC between the anterior cingulate cortex and left precuneus, which was correlated with the tinnitus duration (r=0.451, p=0.007). Moreover, enhanced FC between the posterior cingulate cortex and right medial prefrontal cortex in tinnitus patients was positively correlated with the tinnitus distress (r=0.411, p=0.014). Conclusion: Chronic tinnitus patients showed disrupted FC patterns within the DMN regions which are correlated with tinnitus distress. Increased resting-state connectivity pattern of the DMN may play a pivotal role in neuropathological features underlying chronic tinnitus. Keywords: tinnitus, anterior cingulate cortex, posterior cingulate cortex, default mode network, resting-state fMRIChen YCChen HBo FXu JJDeng YLv HCai YXia WYin XGu JPLu GMDove Medical Pressarticletinnitusanterior cingulate cortexposterior cingulate cortexdefault mode networkresting-state fMRI.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1919-1927 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	tinnitus anterior cingulate cortex posterior cingulate cortex default mode network resting-state fMRI. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	tinnitus anterior cingulate cortex posterior cingulate cortex default mode network resting-state fMRI. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Chen YC Chen H Bo F Xu JJ Deng Y Lv H Cai Y Xia W Yin X Gu JP Lu GM Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
description	Yu-Chen Chen,1,2 Huiyou Chen,2 Fan Bo,2 Jin-Jing Xu,3 Yi Deng,3 Han Lv,4 Yuexin Cai,5 Wenqing Xia,6 Xindao Yin,2 Jian-Ping Gu,2 Guangming Lu1 1Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China; 2Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; 3Department of Otolaryngology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; 4Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; 5Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; 6Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China Purpose: The default mode network (DMN) has been confirmed to be involved in chronic tinnitus perception. Tinnitus distress may be associated with abnormal functional connectivity (FC) within the DMN regions. The goal of this study was to determine whether tinnitus disrupted the FC patterns within the DMN as measured by using resting-state functional magnetic resonance imaging approach. Patients and methods: Resting-state functional magnetic resonance imaging scans were acquired from 40 chronic bilateral tinnitus patients and 41 healthy controls. Both were age, sex, and education well-matched with normal hearing. Two important DMN regions, the anterior cingulate cortex and posterior cingulate cortex, were chosen as seed regions to detect the FC patterns within the DMN and then determine whether these changes were linked to clinical measures of tinnitus such as tinnitus duration and tinnitus severity. Results: Compared with healthy controls, chronic tinnitus patients manifested significantly enhanced FC between the anterior cingulate cortex and left precuneus, which was correlated with the tinnitus duration (r=0.451, p=0.007). Moreover, enhanced FC between the posterior cingulate cortex and right medial prefrontal cortex in tinnitus patients was positively correlated with the tinnitus distress (r=0.411, p=0.014). Conclusion: Chronic tinnitus patients showed disrupted FC patterns within the DMN regions which are correlated with tinnitus distress. Increased resting-state connectivity pattern of the DMN may play a pivotal role in neuropathological features underlying chronic tinnitus. Keywords: tinnitus, anterior cingulate cortex, posterior cingulate cortex, default mode network, resting-state fMRI
format	article
author	Chen YC Chen H Bo F Xu JJ Deng Y Lv H Cai Y Xia W Yin X Gu JP Lu GM
author_facet	Chen YC Chen H Bo F Xu JJ Deng Y Lv H Cai Y Xia W Yin X Gu JP Lu GM
author_sort	Chen YC
title	Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
title_short	Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
title_full	Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
title_fullStr	Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
title_full_unstemmed	Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
title_sort	tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1d360a1a154f443d9ae21cf42a995891
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Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network

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