Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model

Ping Zhang,* Audrey Darmon,* Julie Marill, Naeemunnisa Mohamed Anesary, Sébastien Paris Nanobiotix, Paris, France*These authors contributed equally to this workCorrespondence: Sébastien Paris Email sebastien.paris@nanobiotix.comPurpose: Despite tremendous results achieved by im...

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Autores principales:	Zhang P, Darmon A, Marill J, Mohamed Anesary N, Paris S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cd8+ t cells antitumor immune response tils nbtxr3 radioenhancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1d362899023b4a3096309b30a4789a22
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spelling	oai:doaj.org-article:1d362899023b4a3096309b30a4789a222021-12-02T11:39:59ZRadiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model1178-2013https://doaj.org/article/1d362899023b4a3096309b30a4789a222020-05-01T00:00:00Zhttps://www.dovepress.com/radiotherapy-activated-hafnium-oxide-nanoparticles-produce-abscopal-ef-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ping Zhang,* Audrey Darmon,* Julie Marill, Naeemunnisa Mohamed Anesary, Sébastien Paris Nanobiotix, Paris, France*These authors contributed equally to this workCorrespondence: Sébastien Paris Email sebastien.paris@nanobiotix.comPurpose: Despite tremendous results achieved by immune checkpoint inhibitors, most patients are not responders, mainly because of the lack of a pre-existing anti-tumor immune response. Thus, solutions to efficiently prime this immune response are currently under intensive investigations. Radiotherapy elicits cancer cell death, generating an antitumor-specific T cell response, turning tumors in personalized in situ vaccines, with potentially systemic effects (abscopal effect). Nonetheless, clinical evidence of sustained anti-tumor immunity as abscopal effect are rare.Methods: Hafnium oxide nanoparticles (NBTXR3) have been designed to increase energy dose deposit within cancer cells. We examined the effect of radiotherapy-activated NBTXR3 on anti-tumor immune response activation and abscopal effect production using a mouse colorectal cancer model.Results: We demonstrate that radiotherapy-activated NBTXR3 kill more cancer cells than radiotherapy alone, significantly increase immune cell infiltrates both in treated and in untreated distant tumors, generating an abscopal effect dependent on CD8+ lymphocyte T cells.Conclusion: These data show that radiotherapy-activated NBTXR3 could increase local and distant tumor control through immune system priming. Our results may have important implications for immunotherapeutic agent combination with radiotherapy.Keywords: CD8+ T cells, antitumor immune response, TILs, NBTXR3, radioenhancerZhang PDarmon AMarill JMohamed Anesary NParis SDove Medical Pressarticlecd8+ t cellsantitumor immune responsetilsnbtxr3radioenhancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3843-3850 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cd8+ t cells antitumor immune response tils nbtxr3 radioenhancer Medicine (General) R5-920
spellingShingle	cd8+ t cells antitumor immune response tils nbtxr3 radioenhancer Medicine (General) R5-920 Zhang P Darmon A Marill J Mohamed Anesary N Paris S Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
description	Ping Zhang,* Audrey Darmon,* Julie Marill, Naeemunnisa Mohamed Anesary, Sébastien Paris Nanobiotix, Paris, France*These authors contributed equally to this workCorrespondence: Sébastien Paris Email sebastien.paris@nanobiotix.comPurpose: Despite tremendous results achieved by immune checkpoint inhibitors, most patients are not responders, mainly because of the lack of a pre-existing anti-tumor immune response. Thus, solutions to efficiently prime this immune response are currently under intensive investigations. Radiotherapy elicits cancer cell death, generating an antitumor-specific T cell response, turning tumors in personalized in situ vaccines, with potentially systemic effects (abscopal effect). Nonetheless, clinical evidence of sustained anti-tumor immunity as abscopal effect are rare.Methods: Hafnium oxide nanoparticles (NBTXR3) have been designed to increase energy dose deposit within cancer cells. We examined the effect of radiotherapy-activated NBTXR3 on anti-tumor immune response activation and abscopal effect production using a mouse colorectal cancer model.Results: We demonstrate that radiotherapy-activated NBTXR3 kill more cancer cells than radiotherapy alone, significantly increase immune cell infiltrates both in treated and in untreated distant tumors, generating an abscopal effect dependent on CD8+ lymphocyte T cells.Conclusion: These data show that radiotherapy-activated NBTXR3 could increase local and distant tumor control through immune system priming. Our results may have important implications for immunotherapeutic agent combination with radiotherapy.Keywords: CD8+ T cells, antitumor immune response, TILs, NBTXR3, radioenhancer
format	article
author	Zhang P Darmon A Marill J Mohamed Anesary N Paris S
author_facet	Zhang P Darmon A Marill J Mohamed Anesary N Paris S
author_sort	Zhang P
title	Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
title_short	Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
title_full	Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
title_fullStr	Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
title_full_unstemmed	Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model
title_sort	radiotherapy-activated hafnium oxide nanoparticles produce abscopal effect in a mouse colorectal cancer model
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1d362899023b4a3096309b30a4789a22
work_keys_str_mv	AT zhangp radiotherapyactivatedhafniumoxidenanoparticlesproduceabscopaleffectinamousecolorectalcancermodel AT darmona radiotherapyactivatedhafniumoxidenanoparticlesproduceabscopaleffectinamousecolorectalcancermodel AT marillj radiotherapyactivatedhafniumoxidenanoparticlesproduceabscopaleffectinamousecolorectalcancermodel AT mohamedanesaryn radiotherapyactivatedhafniumoxidenanoparticlesproduceabscopaleffectinamousecolorectalcancermodel AT pariss radiotherapyactivatedhafniumoxidenanoparticlesproduceabscopaleffectinamousecolorectalcancermodel
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Radiotherapy-Activated Hafnium Oxide Nanoparticles Produce Abscopal Effect in a Mouse Colorectal Cancer Model

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