The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents

Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osak...

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Autores principales:	Hiroko Sonoyama, Kaoru Araki-Sasaki, Shigeyasu Kazama, Tsutomu Kawasaki, Hidenao Ideta, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/1d366a784b6940f99423f0c3a83bb53d
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spelling	oai:doaj.org-article:1d366a784b6940f99423f0c3a83bb53d2021-12-02T01:16:06ZThe characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents1177-54671177-5483https://doaj.org/article/1d366a784b6940f99423f0c3a83bb53d2008-10-01T00:00:00Zhttp://www.dovepress.com/the-characteristics-of-keratomycosis-by-embeauveria-bassianaem-and-its-a2422https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 3Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organ, Tottori University, Yonago, Tottori, Japan; 4Immunology and Virology Section Lab, Immunology, NEI, NIH, Bethesda, MD, USAAbstract: Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopathogenic filamentous fungus, are described for an 80-year-old woman, who was referred to the hospital for ocular pain and redness on the 9th day after an ocular injury caused by the frame of her glasses. She had a long history of recurrent diabetic iritis and continuously used topical antibiotics and corticosteroids. At her first visit, a slit-lamp examination indicated a corneal ulcer confined within the superficial stromal layer, along with a slight infiltration and edema. Only a very few inflammatory cells were seen in the anterior chamber. Direct microscopic examination of corneal scrapings revealed septate fungal hyphae with zig-zag rachis and budding that was subsequently identified as B. bassiana by slide culture. Topical voriconazole with miconazole, pimaricin and oral itraconazole were effective and the lesion disappeared leaving only a mild scar at 2 months. The sensitivity of B. bassiana to various antimycotic agents was confirmed by broth microdilution, agar dilution with the Clinical Laboratory Standard Institute standard, and a disk method using topically applied concentrations. B. bassiana, which exhibits a characteristic appearance in smears and causes superficial keratomycosis, is sensitive to voriconazole with miconazole, pimaricin, and itraconazole.Keywords: Beauveria bassiana, keratomycosis, filamentous fungus, voriconazole, corneal infection Hiroko SonoyamaKaoru Araki-SasakiShigeyasu KazamaTsutomu KawasakiHidenao Idetaet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 3, Pp 675-678 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Hiroko Sonoyama Kaoru Araki-Sasaki Shigeyasu Kazama Tsutomu Kawasaki Hidenao Ideta et al The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents
description	Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 3Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organ, Tottori University, Yonago, Tottori, Japan; 4Immunology and Virology Section Lab, Immunology, NEI, NIH, Bethesda, MD, USAAbstract: Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopathogenic filamentous fungus, are described for an 80-year-old woman, who was referred to the hospital for ocular pain and redness on the 9th day after an ocular injury caused by the frame of her glasses. She had a long history of recurrent diabetic iritis and continuously used topical antibiotics and corticosteroids. At her first visit, a slit-lamp examination indicated a corneal ulcer confined within the superficial stromal layer, along with a slight infiltration and edema. Only a very few inflammatory cells were seen in the anterior chamber. Direct microscopic examination of corneal scrapings revealed septate fungal hyphae with zig-zag rachis and budding that was subsequently identified as B. bassiana by slide culture. Topical voriconazole with miconazole, pimaricin and oral itraconazole were effective and the lesion disappeared leaving only a mild scar at 2 months. The sensitivity of B. bassiana to various antimycotic agents was confirmed by broth microdilution, agar dilution with the Clinical Laboratory Standard Institute standard, and a disk method using topically applied concentrations. B. bassiana, which exhibits a characteristic appearance in smears and causes superficial keratomycosis, is sensitive to voriconazole with miconazole, pimaricin, and itraconazole.Keywords: Beauveria bassiana, keratomycosis, filamentous fungus, voriconazole, corneal infection
format	article
author	Hiroko Sonoyama Kaoru Araki-Sasaki Shigeyasu Kazama Tsutomu Kawasaki Hidenao Ideta et al
author_facet	Hiroko Sonoyama Kaoru Araki-Sasaki Shigeyasu Kazama Tsutomu Kawasaki Hidenao Ideta et al
author_sort	Hiroko Sonoyama
title	The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents
title_short	The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents
title_full	The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents
title_fullStr	The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents
title_full_unstemmed	The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents
title_sort	characteristics of keratomycosis by beauveria bassiana and its successful treatment with antimycotic agents
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/1d366a784b6940f99423f0c3a83bb53d
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The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents

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