Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

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Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate immune responses to AAV capsid with AAV-CAR regulat...

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Autores principales:	Motahareh Arjomandnejad, Katelyn Sylvia, Meghan Blackwood, Thomas Nixon, Qiushi Tang, Manish Muhuri, Alisha M. Gruntman, Guangping Gao, Terence R. Flotte, Allison M. Keeler
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	CAR Tregs AAV gene therapy CAR T regulatory cells chimeric antigen receptor T-regulatory cells immunosuppression immune responses to AAV Genetics QH426-470 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/1d3794b4a1154ad0b895efd390f57d2a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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