Esterase mutation is a mechanism of resistance to antimalarial compounds

Pepstatin is a known inhibitor of malarial proteases, but its activity varies between sources. Here, Istvanet al. identify a pepstatin ester as the active component of pepstatin preparations and show that this prodrug is activated by a Plasmodiumesterase, mutation of which can confer resistance to p...

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Autores principales:	Eva S. Istvan, Jeremy P. Mallari, Victoria C. Corey, Neekesh V. Dharia, Garland R. Marshall, Elizabeth A. Winzeler, Daniel E. Goldberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d38f9612f4048a39eb045aecf7bcf36
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spelling	oai:doaj.org-article:1d38f9612f4048a39eb045aecf7bcf362021-12-02T14:41:07ZEsterase mutation is a mechanism of resistance to antimalarial compounds10.1038/ncomms142402041-1723https://doaj.org/article/1d38f9612f4048a39eb045aecf7bcf362017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14240https://doaj.org/toc/2041-1723Pepstatin is a known inhibitor of malarial proteases, but its activity varies between sources. Here, Istvanet al. identify a pepstatin ester as the active component of pepstatin preparations and show that this prodrug is activated by a Plasmodiumesterase, mutation of which can confer resistance to pepstatin and other compounds.Eva S. IstvanJeremy P. MallariVictoria C. CoreyNeekesh V. DhariaGarland R. MarshallElizabeth A. WinzelerDaniel E. GoldbergNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eva S. Istvan Jeremy P. Mallari Victoria C. Corey Neekesh V. Dharia Garland R. Marshall Elizabeth A. Winzeler Daniel E. Goldberg Esterase mutation is a mechanism of resistance to antimalarial compounds
description	Pepstatin is a known inhibitor of malarial proteases, but its activity varies between sources. Here, Istvanet al. identify a pepstatin ester as the active component of pepstatin preparations and show that this prodrug is activated by a Plasmodiumesterase, mutation of which can confer resistance to pepstatin and other compounds.
format	article
author	Eva S. Istvan Jeremy P. Mallari Victoria C. Corey Neekesh V. Dharia Garland R. Marshall Elizabeth A. Winzeler Daniel E. Goldberg
author_facet	Eva S. Istvan Jeremy P. Mallari Victoria C. Corey Neekesh V. Dharia Garland R. Marshall Elizabeth A. Winzeler Daniel E. Goldberg
author_sort	Eva S. Istvan
title	Esterase mutation is a mechanism of resistance to antimalarial compounds
title_short	Esterase mutation is a mechanism of resistance to antimalarial compounds
title_full	Esterase mutation is a mechanism of resistance to antimalarial compounds
title_fullStr	Esterase mutation is a mechanism of resistance to antimalarial compounds
title_full_unstemmed	Esterase mutation is a mechanism of resistance to antimalarial compounds
title_sort	esterase mutation is a mechanism of resistance to antimalarial compounds
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1d38f9612f4048a39eb045aecf7bcf36
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Esterase mutation is a mechanism of resistance to antimalarial compounds

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