Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety

Abstract The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it...

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Autores principales:	Yuko Hakamata, Shotaro Komi, Yoshiya Moriguchi, Shuhei Izawa, Yuki Motomura, Eisuke Sato, Shinya Mizukami, Yoshiharu Kim, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d3afdc8420e4db4a29d9c05c4b876f2
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spelling	oai:doaj.org-article:1d3afdc8420e4db4a29d9c05c4b876f22021-12-02T12:32:51ZAmygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety10.1038/s41598-017-08918-72045-2322https://doaj.org/article/1d3afdc8420e4db4a29d9c05c4b876f22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08918-7https://doaj.org/toc/2045-2322Abstract The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors.Yuko HakamataShotaro KomiYoshiya MoriguchiShuhei IzawaYuki MotomuraEisuke SatoShinya MizukamiYoshiharu KimTakashi HanakawaYusuke InoueHirokuni TagayaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Hakamata Shotaro Komi Yoshiya Moriguchi Shuhei Izawa Yuki Motomura Eisuke Sato Shinya Mizukami Yoshiharu Kim Takashi Hanakawa Yusuke Inoue Hirokuni Tagaya Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
description	Abstract The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors.
format	article
author	Yuko Hakamata Shotaro Komi Yoshiya Moriguchi Shuhei Izawa Yuki Motomura Eisuke Sato Shinya Mizukami Yoshiharu Kim Takashi Hanakawa Yusuke Inoue Hirokuni Tagaya
author_facet	Yuko Hakamata Shotaro Komi Yoshiya Moriguchi Shuhei Izawa Yuki Motomura Eisuke Sato Shinya Mizukami Yoshiharu Kim Takashi Hanakawa Yusuke Inoue Hirokuni Tagaya
author_sort	Yuko Hakamata
title	Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
title_short	Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
title_full	Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
title_fullStr	Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
title_full_unstemmed	Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
title_sort	amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1d3afdc8420e4db4a29d9c05c4b876f2
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Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety

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