Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

Opening of G protein-gated inwardly rectifying potassium channels (GIRK) is coupled to the activation of a GPCR. Here the authors use NMR and cell-based BRET assays to gain insights into the mechanisms underlying family-specific activation and find that pre-formation of the Gαi/oβγ-GIRK complex in t...

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Autores principales:	Hanaho Kano, Yuki Toyama, Shunsuke Imai, Yuta Iwahashi, Yoko Mase, Mariko Yokogawa, Masanori Osawa, Ichio Shimada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d3c5f17ee3f414881ec083bebb5692c
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spelling	oai:doaj.org-article:1d3c5f17ee3f414881ec083bebb5692c2021-12-02T17:01:58ZStructural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel10.1038/s41467-019-10038-x2041-1723https://doaj.org/article/1d3c5f17ee3f414881ec083bebb5692c2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10038-xhttps://doaj.org/toc/2041-1723Opening of G protein-gated inwardly rectifying potassium channels (GIRK) is coupled to the activation of a GPCR. Here the authors use NMR and cell-based BRET assays to gain insights into the mechanisms underlying family-specific activation and find that pre-formation of the Gαi/oβγ-GIRK complex in the inactive state is responsible for specific GIRK activation and present a structural model for the Gαi/oβγ-GIRK complex.Hanaho KanoYuki ToyamaShunsuke ImaiYuta IwahashiYoko MaseMariko YokogawaMasanori OsawaIchio ShimadaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanaho Kano Yuki Toyama Shunsuke Imai Yuta Iwahashi Yoko Mase Mariko Yokogawa Masanori Osawa Ichio Shimada Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
description	Opening of G protein-gated inwardly rectifying potassium channels (GIRK) is coupled to the activation of a GPCR. Here the authors use NMR and cell-based BRET assays to gain insights into the mechanisms underlying family-specific activation and find that pre-formation of the Gαi/oβγ-GIRK complex in the inactive state is responsible for specific GIRK activation and present a structural model for the Gαi/oβγ-GIRK complex.
format	article
author	Hanaho Kano Yuki Toyama Shunsuke Imai Yuta Iwahashi Yoko Mase Mariko Yokogawa Masanori Osawa Ichio Shimada
author_facet	Hanaho Kano Yuki Toyama Shunsuke Imai Yuta Iwahashi Yoko Mase Mariko Yokogawa Masanori Osawa Ichio Shimada
author_sort	Hanaho Kano
title	Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
title_short	Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
title_full	Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
title_fullStr	Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
title_full_unstemmed	Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel
title_sort	structural mechanism underlying g protein family-specific regulation of g protein-gated inwardly rectifying potassium channel
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1d3c5f17ee3f414881ec083bebb5692c
work_keys_str_mv	AT hanahokano structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT yukitoyama structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT shunsukeimai structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT yutaiwahashi structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT yokomase structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT marikoyokogawa structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT masanoriosawa structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel AT ichioshimada structuralmechanismunderlyinggproteinfamilyspecificregulationofgproteingatedinwardlyrectifyingpotassiumchannel
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Structural mechanism underlying G protein family-specific regulation of G protein-gated inwardly rectifying potassium channel

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