Targets identified from exercised heart: killing multiple birds with one stone

Abstract Cardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and excess alcohol use. Exercise targets several molecules and protects hearts against many of these physiological and pathological stimuli. Accord...

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Autores principales:	Hongyun Wang, Yuling Xie, Longfei Guan, Kenneth Elkin, Junjie Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/1d3d83a1aa2b4097b21a4b588f05c30c
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spelling	oai:doaj.org-article:1d3d83a1aa2b4097b21a4b588f05c30c2021-12-02T14:37:28ZTargets identified from exercised heart: killing multiple birds with one stone10.1038/s41536-021-00128-02057-3995https://doaj.org/article/1d3d83a1aa2b4097b21a4b588f05c30c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00128-0https://doaj.org/toc/2057-3995Abstract Cardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and excess alcohol use. Exercise targets several molecules and protects hearts against many of these physiological and pathological stimuli. Accordingly, it is widely recognized as an effective therapeutic strategy for CVD. To investigate the molecular mechanism of exercise in cardiac protection, we identify and describe several crucial targets identified from exercised hearts. These targets include insulin-like growth factor 1 (IGF1)-phosphatidylinositol 3 phosphate kinase (PI3K)/protein kinase B (AKT), transcription factor CCAAT/enhancer-binding protein β (C/EBPβ), cardiac microRNAs (miRNAs, miR-222 and miR-17-3p etc.), exosomal-miRNAs (miR-342, miR-29, etc.), Sirtuin 1 (SIRT1), and nuclear factor erythroid 2‑related factor/metallothioneins (Nrf2/Mts). Targets identified from exercised hearts can alleviate injury via multiple avenues, including: (1) promoting cardiomyocyte proliferation; (2) facilitating cardiomyocyte growth and physiologic hypertrophy; (3) elevating the anti-apoptotic capacity of cardiomyocytes; (4) improving vascular endothelial function; (5) inhibiting pathological remodeling and fibrosis; (6) promoting extracellular vesicles (EVs) production and exosomal-molecules transfer. Exercise is one treatment (‘stone’), which is cardioprotective via multiple avenues (‘birds’), and is considered ‘killing multiple birds with one stone’ in this review. Further, we discuss the potential application of EV cargos in CVD treatment. We provide an outline of targets identified from the exercised heart and their mechanisms, as well as novel ideas for CVD treatment, which may provide novel direction for preclinical trials in cardiac rehabilitation.Hongyun WangYuling XieLongfei GuanKenneth ElkinJunjie XiaoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Hongyun Wang Yuling Xie Longfei Guan Kenneth Elkin Junjie Xiao Targets identified from exercised heart: killing multiple birds with one stone
description	Abstract Cardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and excess alcohol use. Exercise targets several molecules and protects hearts against many of these physiological and pathological stimuli. Accordingly, it is widely recognized as an effective therapeutic strategy for CVD. To investigate the molecular mechanism of exercise in cardiac protection, we identify and describe several crucial targets identified from exercised hearts. These targets include insulin-like growth factor 1 (IGF1)-phosphatidylinositol 3 phosphate kinase (PI3K)/protein kinase B (AKT), transcription factor CCAAT/enhancer-binding protein β (C/EBPβ), cardiac microRNAs (miRNAs, miR-222 and miR-17-3p etc.), exosomal-miRNAs (miR-342, miR-29, etc.), Sirtuin 1 (SIRT1), and nuclear factor erythroid 2‑related factor/metallothioneins (Nrf2/Mts). Targets identified from exercised hearts can alleviate injury via multiple avenues, including: (1) promoting cardiomyocyte proliferation; (2) facilitating cardiomyocyte growth and physiologic hypertrophy; (3) elevating the anti-apoptotic capacity of cardiomyocytes; (4) improving vascular endothelial function; (5) inhibiting pathological remodeling and fibrosis; (6) promoting extracellular vesicles (EVs) production and exosomal-molecules transfer. Exercise is one treatment (‘stone’), which is cardioprotective via multiple avenues (‘birds’), and is considered ‘killing multiple birds with one stone’ in this review. Further, we discuss the potential application of EV cargos in CVD treatment. We provide an outline of targets identified from the exercised heart and their mechanisms, as well as novel ideas for CVD treatment, which may provide novel direction for preclinical trials in cardiac rehabilitation.
format	article
author	Hongyun Wang Yuling Xie Longfei Guan Kenneth Elkin Junjie Xiao
author_facet	Hongyun Wang Yuling Xie Longfei Guan Kenneth Elkin Junjie Xiao
author_sort	Hongyun Wang
title	Targets identified from exercised heart: killing multiple birds with one stone
title_short	Targets identified from exercised heart: killing multiple birds with one stone
title_full	Targets identified from exercised heart: killing multiple birds with one stone
title_fullStr	Targets identified from exercised heart: killing multiple birds with one stone
title_full_unstemmed	Targets identified from exercised heart: killing multiple birds with one stone
title_sort	targets identified from exercised heart: killing multiple birds with one stone
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d3d83a1aa2b4097b21a4b588f05c30c
work_keys_str_mv	AT hongyunwang targetsidentifiedfromexercisedheartkillingmultiplebirdswithonestone AT yulingxie targetsidentifiedfromexercisedheartkillingmultiplebirdswithonestone AT longfeiguan targetsidentifiedfromexercisedheartkillingmultiplebirdswithonestone AT kennethelkin targetsidentifiedfromexercisedheartkillingmultiplebirdswithonestone AT junjiexiao targetsidentifiedfromexercisedheartkillingmultiplebirdswithonestone
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Targets identified from exercised heart: killing multiple birds with one stone

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