Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression
Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disea...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:1d3e26f9c43e49ff91563b693f6cbf322021-11-09T06:24:25ZBerberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression1663-981210.3389/fphar.2021.724525https://doaj.org/article/1d3e26f9c43e49ff91563b693f6cbf322021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.724525/fullhttps://doaj.org/toc/1663-9812Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disease. Berberine (Ber) has fabulous anti-inflammatory and antibacterial effects, while its low water solubility and bioavailability greatly limit its curative efficiency. To improve the nasal mucosa absorption of poorly water-soluble drugs, such as Ber, we developed a platelet membrane- (PM-) coated nanoparticle (NP) system (PM@Ber-NPs) for targeted delivery of berberine to the inflammatory lungs. In vivo, PM@Ber-NPs exhibited enhanced targeting retention in the inflammatory lungs compared with free Ber. In a mouse model of house dust mite- (HDM-) induced asthma, PM@Ber-NPs markedly inhibited lung inflammation, as evident by reduced inflammatory cells and inflammatory cytokines in the lung compared with free Ber. Collectively, our study demonstrated the inhibitory actions of nasally delivered nanomedicines on HDM-induced asthma, primarily through regulating Th1/Th2 balance by enhancing IL-12 expression which could potentially reduce lung inflammation and allergic asthma.Hua JinHua JinJiale LiJiale LiMiaoyuan ZhangMiaoyuan ZhangRenxing LuoRenxing LuoPeishan LuPeishan LuWenting ZhangJunai ZhangJiang PiWeixin ZhengZesen MaiXiaowen DingXinguang LiuSuidong OuyangGonghua HuangFrontiers Media S.A.articleberberinebiomimetic nanoparticlesplatelet membraneasthmaIL-12Therapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021) |
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| topic |
berberine biomimetic nanoparticles platelet membrane asthma IL-12 Therapeutics. Pharmacology RM1-950 |
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berberine biomimetic nanoparticles platelet membrane asthma IL-12 Therapeutics. Pharmacology RM1-950 Hua Jin Hua Jin Jiale Li Jiale Li Miaoyuan Zhang Miaoyuan Zhang Renxing Luo Renxing Luo Peishan Lu Peishan Lu Wenting Zhang Junai Zhang Jiang Pi Weixin Zheng Zesen Mai Xiaowen Ding Xinguang Liu Suidong Ouyang Gonghua Huang Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression |
| description |
Asthma is one of the most common chronic pulmonary disorders, affecting more than 330 million people worldwide. Unfortunately, there are still no specific treatments for asthma so far. Therefore, it is very important to develop effective therapeutics and medicines to deal with this intractable disease. Berberine (Ber) has fabulous anti-inflammatory and antibacterial effects, while its low water solubility and bioavailability greatly limit its curative efficiency. To improve the nasal mucosa absorption of poorly water-soluble drugs, such as Ber, we developed a platelet membrane- (PM-) coated nanoparticle (NP) system (PM@Ber-NPs) for targeted delivery of berberine to the inflammatory lungs. In vivo, PM@Ber-NPs exhibited enhanced targeting retention in the inflammatory lungs compared with free Ber. In a mouse model of house dust mite- (HDM-) induced asthma, PM@Ber-NPs markedly inhibited lung inflammation, as evident by reduced inflammatory cells and inflammatory cytokines in the lung compared with free Ber. Collectively, our study demonstrated the inhibitory actions of nasally delivered nanomedicines on HDM-induced asthma, primarily through regulating Th1/Th2 balance by enhancing IL-12 expression which could potentially reduce lung inflammation and allergic asthma. |
| format |
article |
| author |
Hua Jin Hua Jin Jiale Li Jiale Li Miaoyuan Zhang Miaoyuan Zhang Renxing Luo Renxing Luo Peishan Lu Peishan Lu Wenting Zhang Junai Zhang Jiang Pi Weixin Zheng Zesen Mai Xiaowen Ding Xinguang Liu Suidong Ouyang Gonghua Huang |
| author_facet |
Hua Jin Hua Jin Jiale Li Jiale Li Miaoyuan Zhang Miaoyuan Zhang Renxing Luo Renxing Luo Peishan Lu Peishan Lu Wenting Zhang Junai Zhang Jiang Pi Weixin Zheng Zesen Mai Xiaowen Ding Xinguang Liu Suidong Ouyang Gonghua Huang |
| author_sort |
Hua Jin |
| title |
Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression |
| title_short |
Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression |
| title_full |
Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression |
| title_fullStr |
Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression |
| title_full_unstemmed |
Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression |
| title_sort |
berberine-loaded biomimetic nanoparticles attenuate inflammation of experimental allergic asthma via enhancing il-12 expression |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/1d3e26f9c43e49ff91563b693f6cbf32 |
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