Multimodal characterization of Yucatan minipig behavior and physiology through maturation

Abstract Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries....

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Autores principales:	Alesa H. Netzley, Ryan D. Hunt, Josue Franco-Arellano, Nicole Arnold, Ana I. Vazquez, Kirk A. Munoz, Aimee C. Colbath, Tamara Reid Bush, Galit Pelled
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d3f300361a443678bd9a2e7a4b83dce
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spelling	oai:doaj.org-article:1d3f300361a443678bd9a2e7a4b83dce2021-11-28T12:19:43ZMultimodal characterization of Yucatan minipig behavior and physiology through maturation10.1038/s41598-021-00782-w2045-2322https://doaj.org/article/1d3f300361a443678bd9a2e7a4b83dce2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00782-whttps://doaj.org/toc/2045-2322Abstract Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries. Understanding cognitive, motor, and sensory aspects of pig behavior throughout development is crucial for evaluating cognitive and motor deficits after injury. We have developed a comprehensive battery of tests to characterize the behavior and physiological function of the Yucatan minipig throughout maturation. Behavioral testing included assessments of learning and memory, executive functions, circadian rhythms, gait analysis, and level of motor activity. We applied traditional behavioral apparatus and analysis methods, as well as state-of-the-art sensor technologies to report on motion and activity, and artificial intelligent approaches to analyze behavior. We studied pigs from 16 weeks old through sexual maturity at 35 weeks old. The results show multidimensional characterization of minipig behavior, and how it develops and changes with age. This animal model may capitulate the biomechanical consideration and phenotype of head injuries in the developing brain and can drive forward the field of understanding pathophysiological mechanisms and developing new therapies to accelerate recovery in children who have suffered head trauma.Alesa H. NetzleyRyan D. HuntJosue Franco-ArellanoNicole ArnoldAna I. VazquezKirk A. MunozAimee C. ColbathTamara Reid BushGalit PelledNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alesa H. Netzley Ryan D. Hunt Josue Franco-Arellano Nicole Arnold Ana I. Vazquez Kirk A. Munoz Aimee C. Colbath Tamara Reid Bush Galit Pelled Multimodal characterization of Yucatan minipig behavior and physiology through maturation
description	Abstract Brain injuries induced by external forces are particularly challenging to model experimentally. In recent decades, the domestic pig has been gaining popularity as a highly relevant animal model to address the pathophysiological mechanisms and the biomechanics associated with head injuries. Understanding cognitive, motor, and sensory aspects of pig behavior throughout development is crucial for evaluating cognitive and motor deficits after injury. We have developed a comprehensive battery of tests to characterize the behavior and physiological function of the Yucatan minipig throughout maturation. Behavioral testing included assessments of learning and memory, executive functions, circadian rhythms, gait analysis, and level of motor activity. We applied traditional behavioral apparatus and analysis methods, as well as state-of-the-art sensor technologies to report on motion and activity, and artificial intelligent approaches to analyze behavior. We studied pigs from 16 weeks old through sexual maturity at 35 weeks old. The results show multidimensional characterization of minipig behavior, and how it develops and changes with age. This animal model may capitulate the biomechanical consideration and phenotype of head injuries in the developing brain and can drive forward the field of understanding pathophysiological mechanisms and developing new therapies to accelerate recovery in children who have suffered head trauma.
format	article
author	Alesa H. Netzley Ryan D. Hunt Josue Franco-Arellano Nicole Arnold Ana I. Vazquez Kirk A. Munoz Aimee C. Colbath Tamara Reid Bush Galit Pelled
author_facet	Alesa H. Netzley Ryan D. Hunt Josue Franco-Arellano Nicole Arnold Ana I. Vazquez Kirk A. Munoz Aimee C. Colbath Tamara Reid Bush Galit Pelled
author_sort	Alesa H. Netzley
title	Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_short	Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_full	Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_fullStr	Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_full_unstemmed	Multimodal characterization of Yucatan minipig behavior and physiology through maturation
title_sort	multimodal characterization of yucatan minipig behavior and physiology through maturation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d3f300361a443678bd9a2e7a4b83dce
work_keys_str_mv	AT alesahnetzley multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT ryandhunt multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT josuefrancoarellano multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT nicolearnold multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT anaivazquez multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT kirkamunoz multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT aimeeccolbath multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT tamarareidbush multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation AT galitpelled multimodalcharacterizationofyucatanminipigbehaviorandphysiologythroughmaturation
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Multimodal characterization of Yucatan minipig behavior and physiology through maturation

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