Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.

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Autores principales:	Fan Sun, Liwen Li, Pengrong Yan, Jingjiao Zhou, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d400ac3bbf44a7799867ab4feea7bfd
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spelling	oai:doaj.org-article:1d400ac3bbf44a7799867ab4feea7bfd2021-12-02T16:57:24ZCausative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance10.1038/s41467-019-13331-x2041-1723https://doaj.org/article/1d400ac3bbf44a7799867ab4feea7bfd2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13331-xhttps://doaj.org/toc/2041-1723PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.Fan SunLiwen LiPengrong YanJingjiao ZhouSteven D. ShapiroGutian XiaoZhaoxia QuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fan Sun Liwen Li Pengrong Yan Jingjiao Zhou Steven D. Shapiro Gutian Xiao Zhaoxia Qu Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
description	PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.
format	article
author	Fan Sun Liwen Li Pengrong Yan Jingjiao Zhou Steven D. Shapiro Gutian Xiao Zhaoxia Qu
author_facet	Fan Sun Liwen Li Pengrong Yan Jingjiao Zhou Steven D. Shapiro Gutian Xiao Zhaoxia Qu
author_sort	Fan Sun
title	Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
title_short	Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
title_full	Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
title_fullStr	Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
title_full_unstemmed	Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
title_sort	causative role of pdlim2 epigenetic repression in lung cancer and therapeutic resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1d400ac3bbf44a7799867ab4feea7bfd
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_version_	1718382549908062208

Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance

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