Causative role of PDLIM2 epigenetic repression in lung cancer and therapeutic resistance
PDLIM2 is repressed epigenetically in lung cancers, which are frequently resistant to anti-PD-1/PD-L1 and chemotherapy. Here, the authors describe the mechanism through which epigenetic restoration of PDLIM2 synergises with anti-PD-1 and chemotherapy in lung cancers.
Guardado en:
Autores principales: | Fan Sun, Liwen Li, Pengrong Yan, Jingjiao Zhou, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
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Materias: | |
Acceso en línea: | https://doaj.org/article/1d400ac3bbf44a7799867ab4feea7bfd |
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