The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

Signals mediating tissue-specific control of immune cell fate and function remain largely uncharacterized. Here the authors uncover a requirement of ITK, a kinase mediating TCR signaling, for IL-2-dependent ILC2 cell survival specifically in the intestine.

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Autores principales:	Hyoung-Soo Cho, Andrea Reboldi, Jason A. Hall, Leslie J. Berg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d4279bb99b54c9a90b4d5b38b6101b5
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spelling	oai:doaj.org-article:1d4279bb99b54c9a90b4d5b38b6101b52021-12-02T16:58:14ZThe Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine10.1038/s41467-019-08699-92041-1723https://doaj.org/article/1d4279bb99b54c9a90b4d5b38b6101b52019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08699-9https://doaj.org/toc/2041-1723Signals mediating tissue-specific control of immune cell fate and function remain largely uncharacterized. Here the authors uncover a requirement of ITK, a kinase mediating TCR signaling, for IL-2-dependent ILC2 cell survival specifically in the intestine.Hyoung-Soo ChoAndrea ReboldiJason A. HallLeslie J. BergNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyoung-Soo Cho Andrea Reboldi Jason A. Hall Leslie J. Berg The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
description	Signals mediating tissue-specific control of immune cell fate and function remain largely uncharacterized. Here the authors uncover a requirement of ITK, a kinase mediating TCR signaling, for IL-2-dependent ILC2 cell survival specifically in the intestine.
format	article
author	Hyoung-Soo Cho Andrea Reboldi Jason A. Hall Leslie J. Berg
author_facet	Hyoung-Soo Cho Andrea Reboldi Jason A. Hall Leslie J. Berg
author_sort	Hyoung-Soo Cho
title	The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
title_short	The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
title_full	The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
title_fullStr	The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
title_full_unstemmed	The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
title_sort	tec kinase itk is essential for ilc2 survival and epithelial integrity in the intestine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1d4279bb99b54c9a90b4d5b38b6101b5
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The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

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