Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women

Jakub Kortas,1 Ewa Ziemann,2 Jedrzej Antosiewicz3 1Department of Sport, Gdansk University of Physical Education and Sport, Gdansk, Poland; 2Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 3Department of Bioenergetics and Physiology of Exer...

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Autores principales:	Kortas J, Ziemann E, Antosiewicz J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	physical activity ferritin inflammation glucose Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1d44f0cfc94c4ca4b96e8a9d01c41264
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spelling	oai:doaj.org-article:1d44f0cfc94c4ca4b96e8a9d01c412642021-12-02T08:24:04ZEffect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women1178-1998https://doaj.org/article/1d44f0cfc94c4ca4b96e8a9d01c412642020-05-01T00:00:00Zhttps://www.dovepress.com/effect-of-hfe-gene-mutation-on-changes-in-iron-metabolism-induced-by-n-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jakub Kortas,1 Ewa Ziemann,2 Jedrzej Antosiewicz3 1Department of Sport, Gdansk University of Physical Education and Sport, Gdansk, Poland; 2Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 3Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Gdansk, PolandCorrespondence: Jakub KortasDepartment of Sport, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, Gdansk 80-336, PolandEmail jakub.kortas@awfis.gda.plJedrzej AntosiewiczDepartment of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Marii Skłodowskiej-Curie 3a, Gdansk 80-210, PolandEmail jant@gumed.edu.plBackground: Excess iron accumulation in human tissue is associated with the diet, lack of exercise, or genetic factors. Iron accumulation increases the risk of acute myocardial infarction, diabetes, and cancer. On the other hand, exercise reduces the risk of several morbidities and influences iron metabolism. Here, we evaluated changes in iron metabolism induced by exercise in elderly women bearing the H63A HFE mutation.Purpose: To identify a factor that modulates the effect of exercise on iron metabolism. We investigated whether regular exercise induces similar changes in iron metabolism, mainly manifested by lowered body iron stores, in individuals bearing the wild-type (WT) and mutated HFE gene.Subjects and Methods: Seventy-six women (average age 69.2± 5.6 years old) were enrolled in the study. Thirty-nine women participated in 12 weeks of Nordic walking (NW) training; the remaining participants were assigned to the control group. Based on the H63A HFE mutation status, the NW group was divided into women bearing the mutation (HET, n=12) and women with the WT gene (WT, n=27).Results: The training resulted in a statistically significant reduction in the serum iron (p=0.03) and ferritin levels (p=0.001); hepcidin levels remained unchanged. No differences in these parameters were noted between the HET and WT groups.Conclusion: These observations suggest that a reduction in body iron stores might constitute an important aspect of the health-promoting effect of exercise, regardless of the genetic background.Keywords: physical activity, ferritin, inflammation, glucoseKortas JZiemann EAntosiewicz JDove Medical Pressarticlephysical activityferritininflammationglucoseGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 15, Pp 663-671 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	physical activity ferritin inflammation glucose Geriatrics RC952-954.6
spellingShingle	physical activity ferritin inflammation glucose Geriatrics RC952-954.6 Kortas J Ziemann E Antosiewicz J Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
description	Jakub Kortas,1 Ewa Ziemann,2 Jedrzej Antosiewicz3 1Department of Sport, Gdansk University of Physical Education and Sport, Gdansk, Poland; 2Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 3Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Gdansk, PolandCorrespondence: Jakub KortasDepartment of Sport, Gdansk University of Physical Education and Sport, Kazimierza Górskiego 1, Gdansk 80-336, PolandEmail jakub.kortas@awfis.gda.plJedrzej AntosiewiczDepartment of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Marii Skłodowskiej-Curie 3a, Gdansk 80-210, PolandEmail jant@gumed.edu.plBackground: Excess iron accumulation in human tissue is associated with the diet, lack of exercise, or genetic factors. Iron accumulation increases the risk of acute myocardial infarction, diabetes, and cancer. On the other hand, exercise reduces the risk of several morbidities and influences iron metabolism. Here, we evaluated changes in iron metabolism induced by exercise in elderly women bearing the H63A HFE mutation.Purpose: To identify a factor that modulates the effect of exercise on iron metabolism. We investigated whether regular exercise induces similar changes in iron metabolism, mainly manifested by lowered body iron stores, in individuals bearing the wild-type (WT) and mutated HFE gene.Subjects and Methods: Seventy-six women (average age 69.2± 5.6 years old) were enrolled in the study. Thirty-nine women participated in 12 weeks of Nordic walking (NW) training; the remaining participants were assigned to the control group. Based on the H63A HFE mutation status, the NW group was divided into women bearing the mutation (HET, n=12) and women with the WT gene (WT, n=27).Results: The training resulted in a statistically significant reduction in the serum iron (p=0.03) and ferritin levels (p=0.001); hepcidin levels remained unchanged. No differences in these parameters were noted between the HET and WT groups.Conclusion: These observations suggest that a reduction in body iron stores might constitute an important aspect of the health-promoting effect of exercise, regardless of the genetic background.Keywords: physical activity, ferritin, inflammation, glucose
format	article
author	Kortas J Ziemann E Antosiewicz J
author_facet	Kortas J Ziemann E Antosiewicz J
author_sort	Kortas J
title	Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
title_short	Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
title_full	Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
title_fullStr	Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
title_full_unstemmed	Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women
title_sort	effect of hfe gene mutation on changes in iron metabolism induced by nordic walking in elderly women
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/1d44f0cfc94c4ca4b96e8a9d01c41264
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Effect of HFE Gene Mutation on Changes in Iron Metabolism Induced by Nordic Walking in Elderly Women

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