MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.

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Detalles Bibliográficos
Autores principales: Wenyuan Wang, Tonis Org, Amélie Montel-Hagen, Peter D. Pioli, Dan Duan, Edo Israely, Daniel Malkin, Trent Su, Johanna Flach, Siavash K. Kurdistani, Robert H. Schiestl, Hanna K. A. Mikkola
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/1d452816437f47b692bbf01bc2f3c474
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Descripción
Sumario:MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.

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