MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.

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Autores principales:	Wenyuan Wang, Tonis Org, Amélie Montel-Hagen, Peter D. Pioli, Dan Duan, Edo Israely, Daniel Malkin, Trent Su, Johanna Flach, Siavash K. Kurdistani, Robert H. Schiestl, Hanna K. A. Mikkola
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d452816437f47b692bbf01bc2f3c474
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spelling	oai:doaj.org-article:1d452816437f47b692bbf01bc2f3c4742021-12-02T17:31:33ZMEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis10.1038/ncomms123762041-1723https://doaj.org/article/1d452816437f47b692bbf01bc2f3c4742016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12376https://doaj.org/toc/2041-1723MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.Wenyuan WangTonis OrgAmélie Montel-HagenPeter D. PioliDan DuanEdo IsraelyDaniel MalkinTrent SuJohanna FlachSiavash K. KurdistaniRobert H. SchiestlHanna K. A. MikkolaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenyuan Wang Tonis Org Amélie Montel-Hagen Peter D. Pioli Dan Duan Edo Israely Daniel Malkin Trent Su Johanna Flach Siavash K. Kurdistani Robert H. Schiestl Hanna K. A. Mikkola MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
description	MEF2C is a transcription factor required for B-cell proliferation. Here the authors show that MEF2C is also needed in B-cell development and recovery from stress by inducing expression of DNA repair factors that prevent double stranded breaks and enable VDJ recombination.
format	article
author	Wenyuan Wang Tonis Org Amélie Montel-Hagen Peter D. Pioli Dan Duan Edo Israely Daniel Malkin Trent Su Johanna Flach Siavash K. Kurdistani Robert H. Schiestl Hanna K. A. Mikkola
author_facet	Wenyuan Wang Tonis Org Amélie Montel-Hagen Peter D. Pioli Dan Duan Edo Israely Daniel Malkin Trent Su Johanna Flach Siavash K. Kurdistani Robert H. Schiestl Hanna K. A. Mikkola
author_sort	Wenyuan Wang
title	MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
title_short	MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
title_full	MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
title_fullStr	MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
title_full_unstemmed	MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis
title_sort	mef2c protects bone marrow b-lymphoid progenitors during stress haematopoiesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1d452816437f47b692bbf01bc2f3c474
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MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis

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