Clinical manifestations of cuticular drusen in Korean patients

Abstract Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows ethnic differences. We investigated...

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Autores principales:	Dong Hoon Shin, Mingui Kong, Gyule Han, Jong Chul Han, Don-Il Ham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d456229d36b4968bc1fa040eab4d28e
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spelling	oai:doaj.org-article:1d456229d36b4968bc1fa040eab4d28e2021-12-02T15:39:40ZClinical manifestations of cuticular drusen in Korean patients10.1038/s41598-020-68493-22045-2322https://doaj.org/article/1d456229d36b4968bc1fa040eab4d28e2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68493-2https://doaj.org/toc/2045-2322Abstract Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows ethnic differences. We investigated clinical manifestations of cuticular drusen in Korean patients to evaluate possible ethnic differences. Clinical records of Korean patients with cuticular drusen were retrospectively reviewed. Fundus distribution pattern, imaging features, and presence of large drusen, drusenoid pigment epithelial detachment (PED), and macular complications, including geographic atrophy (GA), choroidal neovascularization (CNV), and acquired vitelliform lesion (AVL), were assessed via multimodal imaging in 162 eyes with cuticular drusen (n = 81 patients; 67 females; mean age: 66.6 ± 9.1 years). Diffuse distribution was found in 61.7% and peripapillary involvement in 75.3% of eyes. Large drusen, drusenoid PED, GA, CNV, and AVL were observed in 59.3%, 26.5%, 18.5%, 3.7%, and 1.2% of eyes, respectively. The macular complication prevalence was similar between patients ≤ 60 and those > 60 years old. In Korean patients, cuticular drusen were less frequently associated with macular complications than in white patients, and the proportion of macular complications differed significantly, with AVL representing an uncommon complication.Dong Hoon ShinMingui KongGyule HanJong Chul HanDon-Il HamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Hoon Shin Mingui Kong Gyule Han Jong Chul Han Don-Il Ham Clinical manifestations of cuticular drusen in Korean patients
description	Abstract Cuticular drusen show some similarities to and differences from soft drusen in age-related macular degeneration (AMD) and might thus be a unique AMD subtype. Previous studies on cuticular drusen were performed mainly in white ethnic groups, but AMD shows ethnic differences. We investigated clinical manifestations of cuticular drusen in Korean patients to evaluate possible ethnic differences. Clinical records of Korean patients with cuticular drusen were retrospectively reviewed. Fundus distribution pattern, imaging features, and presence of large drusen, drusenoid pigment epithelial detachment (PED), and macular complications, including geographic atrophy (GA), choroidal neovascularization (CNV), and acquired vitelliform lesion (AVL), were assessed via multimodal imaging in 162 eyes with cuticular drusen (n = 81 patients; 67 females; mean age: 66.6 ± 9.1 years). Diffuse distribution was found in 61.7% and peripapillary involvement in 75.3% of eyes. Large drusen, drusenoid PED, GA, CNV, and AVL were observed in 59.3%, 26.5%, 18.5%, 3.7%, and 1.2% of eyes, respectively. The macular complication prevalence was similar between patients ≤ 60 and those > 60 years old. In Korean patients, cuticular drusen were less frequently associated with macular complications than in white patients, and the proportion of macular complications differed significantly, with AVL representing an uncommon complication.
format	article
author	Dong Hoon Shin Mingui Kong Gyule Han Jong Chul Han Don-Il Ham
author_facet	Dong Hoon Shin Mingui Kong Gyule Han Jong Chul Han Don-Il Ham
author_sort	Dong Hoon Shin
title	Clinical manifestations of cuticular drusen in Korean patients
title_short	Clinical manifestations of cuticular drusen in Korean patients
title_full	Clinical manifestations of cuticular drusen in Korean patients
title_fullStr	Clinical manifestations of cuticular drusen in Korean patients
title_full_unstemmed	Clinical manifestations of cuticular drusen in Korean patients
title_sort	clinical manifestations of cuticular drusen in korean patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1d456229d36b4968bc1fa040eab4d28e
work_keys_str_mv	AT donghoonshin clinicalmanifestationsofcuticulardruseninkoreanpatients AT minguikong clinicalmanifestationsofcuticulardruseninkoreanpatients AT gyulehan clinicalmanifestationsofcuticulardruseninkoreanpatients AT jongchulhan clinicalmanifestationsofcuticulardruseninkoreanpatients AT donilham clinicalmanifestationsofcuticulardruseninkoreanpatients
_version_	1718385858109767680

Clinical manifestations of cuticular drusen in Korean patients

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