Tissue context determines the penetrance of regulatory DNA variation

The functional consequences of variation in human regulatory DNA depend on the local chromatin environment and the cell/tissue context. Here the authors use highly diverged hybrid mice to study genetic effects on DNA accessibility in vivo across multiple cell and tissue types.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jessica M. Halow, Rachel Byron, Megan S. Hogan, Raquel Ordoñez, Mark Groudine, M. A. Bender, John A. Stamatoyannopoulos, Matthew T. Maurano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d484e6b9c4d452395c7af6a519b4e6c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1d484e6b9c4d452395c7af6a519b4e6c
record_format	dspace
spelling	oai:doaj.org-article:1d484e6b9c4d452395c7af6a519b4e6c2021-12-02T15:54:54ZTissue context determines the penetrance of regulatory DNA variation10.1038/s41467-021-23139-32041-1723https://doaj.org/article/1d484e6b9c4d452395c7af6a519b4e6c2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23139-3https://doaj.org/toc/2041-1723The functional consequences of variation in human regulatory DNA depend on the local chromatin environment and the cell/tissue context. Here the authors use highly diverged hybrid mice to study genetic effects on DNA accessibility in vivo across multiple cell and tissue types.Jessica M. HalowRachel ByronMegan S. HoganRaquel OrdoñezMark GroudineM. A. BenderJohn A. StamatoyannopoulosMatthew T. MauranoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica M. Halow Rachel Byron Megan S. Hogan Raquel Ordoñez Mark Groudine M. A. Bender John A. Stamatoyannopoulos Matthew T. Maurano Tissue context determines the penetrance of regulatory DNA variation
description	The functional consequences of variation in human regulatory DNA depend on the local chromatin environment and the cell/tissue context. Here the authors use highly diverged hybrid mice to study genetic effects on DNA accessibility in vivo across multiple cell and tissue types.
format	article
author	Jessica M. Halow Rachel Byron Megan S. Hogan Raquel Ordoñez Mark Groudine M. A. Bender John A. Stamatoyannopoulos Matthew T. Maurano
author_facet	Jessica M. Halow Rachel Byron Megan S. Hogan Raquel Ordoñez Mark Groudine M. A. Bender John A. Stamatoyannopoulos Matthew T. Maurano
author_sort	Jessica M. Halow
title	Tissue context determines the penetrance of regulatory DNA variation
title_short	Tissue context determines the penetrance of regulatory DNA variation
title_full	Tissue context determines the penetrance of regulatory DNA variation
title_fullStr	Tissue context determines the penetrance of regulatory DNA variation
title_full_unstemmed	Tissue context determines the penetrance of regulatory DNA variation
title_sort	tissue context determines the penetrance of regulatory dna variation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d484e6b9c4d452395c7af6a519b4e6c
work_keys_str_mv	AT jessicamhalow tissuecontextdeterminesthepenetranceofregulatorydnavariation AT rachelbyron tissuecontextdeterminesthepenetranceofregulatorydnavariation AT meganshogan tissuecontextdeterminesthepenetranceofregulatorydnavariation AT raquelordonez tissuecontextdeterminesthepenetranceofregulatorydnavariation AT markgroudine tissuecontextdeterminesthepenetranceofregulatorydnavariation AT mabender tissuecontextdeterminesthepenetranceofregulatorydnavariation AT johnastamatoyannopoulos tissuecontextdeterminesthepenetranceofregulatorydnavariation AT matthewtmaurano tissuecontextdeterminesthepenetranceofregulatorydnavariation
_version_	1718385436789833728

Tissue context determines the penetrance of regulatory DNA variation

Ejemplares similares