Recovery of crystallographic texture in remineralized dental enamel.

Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about t...

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Autores principales:	Samera Siddiqui, Paul Anderson, Maisoon Al-Jawad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d48c84784a142d79fcc1e476627b55f
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spelling	oai:doaj.org-article:1d48c84784a142d79fcc1e476627b55f2021-11-25T05:54:53ZRecovery of crystallographic texture in remineralized dental enamel.1932-620310.1371/journal.pone.0108879https://doaj.org/article/1d48c84784a142d79fcc1e476627b55f2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0108879https://doaj.org/toc/1932-6203Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.Samera SiddiquiPaul AndersonMaisoon Al-JawadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e108879 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samera Siddiqui Paul Anderson Maisoon Al-Jawad Recovery of crystallographic texture in remineralized dental enamel.
description	Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
format	article
author	Samera Siddiqui Paul Anderson Maisoon Al-Jawad
author_facet	Samera Siddiqui Paul Anderson Maisoon Al-Jawad
author_sort	Samera Siddiqui
title	Recovery of crystallographic texture in remineralized dental enamel.
title_short	Recovery of crystallographic texture in remineralized dental enamel.
title_full	Recovery of crystallographic texture in remineralized dental enamel.
title_fullStr	Recovery of crystallographic texture in remineralized dental enamel.
title_full_unstemmed	Recovery of crystallographic texture in remineralized dental enamel.
title_sort	recovery of crystallographic texture in remineralized dental enamel.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1d48c84784a142d79fcc1e476627b55f
work_keys_str_mv	AT samerasiddiqui recoveryofcrystallographictextureinremineralizeddentalenamel AT paulanderson recoveryofcrystallographictextureinremineralizeddentalenamel AT maisoonaljawad recoveryofcrystallographictextureinremineralizeddentalenamel
_version_	1718414386096242688

Recovery of crystallographic texture in remineralized dental enamel.

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