Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid Palythoa aff. clavata

Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, Leishmania spp. and Trypanosoma cruzi, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carlos J. Bethencourt-Estrella, Nathalia Nocchi, Atteneri López-Arencibia, Desirée San Nicolás-Hernández, María L. Souto, Blanca Suárez-Gómez, Ana R. Díaz-Marrero, José J. Fernández, Jacob Lorenzo-Morales, José E. Piñero
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	kinetoplastids <i>Trypanosoma</i> <i>Leishmania</i> leishmanicidal Chagas trypanocidal Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1d4a2e353eff45508024a989a9968298
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1d4a2e353eff45508024a989a9968298
record_format	dspace
spelling	oai:doaj.org-article:1d4a2e353eff45508024a989a99682982021-11-25T18:39:17ZAntikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>10.3390/ph141110951424-8247https://doaj.org/article/1d4a2e353eff45508024a989a99682982021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1095https://doaj.org/toc/1424-8247Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, <i>Leishmania</i> spp. and <i>Trypanosoma cruzi</i>, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease, visceral leishmaniasis and megacolon, among others. Current treatments for these diseases are not very effective and highly toxic, since they require very prolonged treatments. The development of innovative, effective and safe drugs to fight infections caused by these parasites remains a challenge. For this reason, in recent years, there has been an increase in the search for new therapies. In this study, the antikinetoplastid activity of 13 sesquiterpene lactones obtained from <i>Palythoa aff. clavata</i> was screened against <i>L. amazonensis</i>, <i>L. donovani</i> and <i>T. cruzi</i>. The results revealed that the sesquiterpene lactones anhydroartemorin (<b>2</b>), <i>cis,trans</i>-costunolide-14-acetate (<b>3</b>) and 4-hydroxyarbusculin A (<b>11</b>) were the most selective against the kinetoplastid species studied. These molecules seem to induce the mechanisms involved in an apoptotic-like death or programmed cell death (PCD) in the kinetoplastids, and since they do not cause necrosis, the inflammatory events associated with this type of cell death will not be triggered.Carlos J. Bethencourt-EstrellaNathalia NocchiAtteneri López-ArencibiaDesirée San Nicolás-HernándezMaría L. SoutoBlanca Suárez-GómezAna R. Díaz-MarreroJosé J. FernándezJacob Lorenzo-MoralesJosé E. PiñeroMDPI AGarticlekinetoplastids<i>Trypanosoma</i><i>Leishmania</i>leishmanicidalChagastrypanocidalMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1095, p 1095 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	kinetoplastids <i>Trypanosoma</i> <i>Leishmania</i> leishmanicidal Chagas trypanocidal Medicine R Pharmacy and materia medica RS1-441
spellingShingle	kinetoplastids <i>Trypanosoma</i> <i>Leishmania</i> leishmanicidal Chagas trypanocidal Medicine R Pharmacy and materia medica RS1-441 Carlos J. Bethencourt-Estrella Nathalia Nocchi Atteneri López-Arencibia Desirée San Nicolás-Hernández María L. Souto Blanca Suárez-Gómez Ana R. Díaz-Marrero José J. Fernández Jacob Lorenzo-Morales José E. Piñero Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>
description	Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, <i>Leishmania</i> spp. and <i>Trypanosoma cruzi</i>, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease, visceral leishmaniasis and megacolon, among others. Current treatments for these diseases are not very effective and highly toxic, since they require very prolonged treatments. The development of innovative, effective and safe drugs to fight infections caused by these parasites remains a challenge. For this reason, in recent years, there has been an increase in the search for new therapies. In this study, the antikinetoplastid activity of 13 sesquiterpene lactones obtained from <i>Palythoa aff. clavata</i> was screened against <i>L. amazonensis</i>, <i>L. donovani</i> and <i>T. cruzi</i>. The results revealed that the sesquiterpene lactones anhydroartemorin (<b>2</b>), <i>cis,trans</i>-costunolide-14-acetate (<b>3</b>) and 4-hydroxyarbusculin A (<b>11</b>) were the most selective against the kinetoplastid species studied. These molecules seem to induce the mechanisms involved in an apoptotic-like death or programmed cell death (PCD) in the kinetoplastids, and since they do not cause necrosis, the inflammatory events associated with this type of cell death will not be triggered.
format	article
author	Carlos J. Bethencourt-Estrella Nathalia Nocchi Atteneri López-Arencibia Desirée San Nicolás-Hernández María L. Souto Blanca Suárez-Gómez Ana R. Díaz-Marrero José J. Fernández Jacob Lorenzo-Morales José E. Piñero
author_facet	Carlos J. Bethencourt-Estrella Nathalia Nocchi Atteneri López-Arencibia Desirée San Nicolás-Hernández María L. Souto Blanca Suárez-Gómez Ana R. Díaz-Marrero José J. Fernández Jacob Lorenzo-Morales José E. Piñero
author_sort	Carlos J. Bethencourt-Estrella
title	Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>
title_short	Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>
title_full	Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>
title_fullStr	Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>
title_full_unstemmed	Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>
title_sort	antikinetoplastid activity of sesquiterpenes isolated from the zoanthid <i>palythoa aff. clavata</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1d4a2e353eff45508024a989a9968298
work_keys_str_mv	AT carlosjbethencourtestrella antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT nathalianocchi antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT attenerilopezarencibia antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT desireesannicolashernandez antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT marialsouto antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT blancasuarezgomez antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT anardiazmarrero antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT josejfernandez antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT jacoblorenzomorales antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai AT joseepinero antikinetoplastidactivityofsesquiterpenesisolatedfromthezoanthidipalythoaaffclavatai
_version_	1718410821143363584

Antikinetoplastid Activity of Sesquiterpenes Isolated from the Zoanthid <i>Palythoa aff. clavata</i>

Ejemplares similares