Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain

Background and Objective: The control of pain in dentistry is one of the important aims. Up to now, some drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen with or without codeine have been used for this purpose. With regard to the effect of caffeine in increasing of the sto...

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Autores principales:	ZS Madani, AK Moghadam Nia, M Haji Ahmadi, B Shafizadeh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2002
Materias:	acetaminophen codeine caffeine acute apical periodentitis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1d4b5aa3170647ef931be0adb2c4af1a
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spelling	oai:doaj.org-article:1d4b5aa3170647ef931be0adb2c4af1a2021-11-10T09:19:40ZComparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain1561-41072251-7170https://doaj.org/article/1d4b5aa3170647ef931be0adb2c4af1a2002-07-01T00:00:00Zhttp://jbums.org/article-1-2818-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: The control of pain in dentistry is one of the important aims. Up to now, some drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen with or without codeine have been used for this purpose. With regard to the effect of caffeine in increasing of the stomach acid secretion and intestinal movements, it seems that caffeine can increase the absorption of Acetaminophen with and without codeine. Methods: This experimental study was performed by simple sampling method and as double blind on 60 patients with acute apical periodentitis due to disease and necrosis of pulp. Drugs and groups were as follows: 1) Acetaminophen (325mg)+placebo powder. 2) Acetaminophen (325mg)+Caffeine (1mg). 3) Acetaminophen codeine (325.15mg)+placebo powder. 4) Acetaminophen codeine (325.15mg)+Caffeine (1mg). Only a single dose of drugs was randomly administered to each patient. The rate of the pain was recorded on the form by using visual analogue scale method (Numerical 0-10) every 10 minutes for 120 minutes. Findings: The process of decreasing pain intensity was different in four groups but this difference was not statistically significant. In the analysis of two combined drugs, the group with caffeine showed better responses in decreasing the pain. Although, there was not a statistically significant difference. Conclusion: According to the obtained results, it seems that adding caffeine to Acetaminophen can induce similar effectiveness with Acetaminophen with codeine in control of the pain due to apical periodentitis.ZS MadaniAK Moghadam NiaM Haji AhmadiB ShafizadehBabol University of Medical Sciencesarticleacetaminophencodeinecaffeineacute apical periodentitisMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 4, Iss 3, Pp 23-27 (2002)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	acetaminophen codeine caffeine acute apical periodentitis Medicine R Medicine (General) R5-920
spellingShingle	acetaminophen codeine caffeine acute apical periodentitis Medicine R Medicine (General) R5-920 ZS Madani AK Moghadam Nia M Haji Ahmadi B Shafizadeh Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain
description	Background and Objective: The control of pain in dentistry is one of the important aims. Up to now, some drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen with or without codeine have been used for this purpose. With regard to the effect of caffeine in increasing of the stomach acid secretion and intestinal movements, it seems that caffeine can increase the absorption of Acetaminophen with and without codeine. Methods: This experimental study was performed by simple sampling method and as double blind on 60 patients with acute apical periodentitis due to disease and necrosis of pulp. Drugs and groups were as follows: 1) Acetaminophen (325mg)+placebo powder. 2) Acetaminophen (325mg)+Caffeine (1mg). 3) Acetaminophen codeine (325.15mg)+placebo powder. 4) Acetaminophen codeine (325.15mg)+Caffeine (1mg). Only a single dose of drugs was randomly administered to each patient. The rate of the pain was recorded on the form by using visual analogue scale method (Numerical 0-10) every 10 minutes for 120 minutes. Findings: The process of decreasing pain intensity was different in four groups but this difference was not statistically significant. In the analysis of two combined drugs, the group with caffeine showed better responses in decreasing the pain. Although, there was not a statistically significant difference. Conclusion: According to the obtained results, it seems that adding caffeine to Acetaminophen can induce similar effectiveness with Acetaminophen with codeine in control of the pain due to apical periodentitis.
format	article
author	ZS Madani AK Moghadam Nia M Haji Ahmadi B Shafizadeh
author_facet	ZS Madani AK Moghadam Nia M Haji Ahmadi B Shafizadeh
author_sort	ZS Madani
title	Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain
title_short	Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain
title_full	Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain
title_fullStr	Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain
title_full_unstemmed	Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain
title_sort	comparison of analgesic effects of acetaminophen and acetaminophen codeine with or without caffeine in control of post acute apical periodentitis pain
publisher	Babol University of Medical Sciences
publishDate	2002
url	https://doaj.org/article/1d4b5aa3170647ef931be0adb2c4af1a
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Comparison of analgesic effects of Acetaminophen and Acetaminophen Codeine with or without Caffeine in control of post acute apical periodentitis pain

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