Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.

<h4>Background</h4>To date, few risk factors for childhood acute lymphoblastic leukemia (ALL) have been confirmed and the scientific literature is full of controversial "evidence." We examined if family characteristics, particularly maternal and paternal age and number of older...

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Autores principales:	Martin Feller, Martin Adam, Marcel Zwahlen, Pierluigi Brazzola, Felix Niggli, Claudia Kuehni, Swiss Pediatric Oncology Group (SPOG), Swiss National Cohort (SNC)
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d4b5ea447934776979b65c046647a65
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spelling	oai:doaj.org-article:1d4b5ea447934776979b65c046647a652021-11-18T07:03:41ZFamily characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.1932-620310.1371/journal.pone.0013156https://doaj.org/article/1d4b5ea447934776979b65c046647a652010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20957179/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To date, few risk factors for childhood acute lymphoblastic leukemia (ALL) have been confirmed and the scientific literature is full of controversial "evidence." We examined if family characteristics, particularly maternal and paternal age and number of older siblings, were risk factors for childhood acute lymphoblastic leukemia (ALL).<h4>Methodology/principal findings</h4>In this population-based nationwide matched case-control study, patients 0-14 years of age with ALL diagnosed 1991-2006 and registered in the Swiss Childhood Cancer Registry were linked with their census records of 1990 and 2000. Eight controls per case were selected from the census. The association between family characteristics and ALL was analyzed by conditional logistic regressions. We found that increasing maternal age was associated with incidence of ALL in the offspring (OR per 5-year increase in maternal age 1.18, 95% CI 1.05-1.31; p = 0.004), remaining stable (trend OR 1.14, 95% CI 0.99-1.31; p = 0.060) after adjustment for other risk factors. The association with paternal age was weaker (OR per 5-year increase 1.14, 95% CI 1.01-1.28, p = 0.032) and disappeared after adjustments. Number of older siblings was not associated with risk of ALL in the overall group of children aged 0-14 years at diagnosis. However, we found a negative trend between number of older siblings and ALL diagnosed at age 0-4 years (OR per sibling 0.85, 95% CI 0.68-1.06; p = 0.141) and a positive trend for ALL diagnosed at age 5-9 (OR 1.34, 95% CI 1.05-1.72; p = 0.019), with some evidence for an effect modification (p-value for interaction = 0.040).<h4>Conclusions</h4>As in other studies, increasing maternal, but not paternal age was associated with risk of ALL. We found only a weak association with the number of older siblings, suggesting a delay in disease manifestation rather than a decrease in incidence.Martin FellerMartin AdamMarcel ZwahlenPierluigi BrazzolaFelix NiggliClaudia KuehniSwiss Pediatric Oncology Group (SPOG)Swiss National Cohort (SNC)Public Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Feller Martin Adam Marcel Zwahlen Pierluigi Brazzola Felix Niggli Claudia Kuehni Swiss Pediatric Oncology Group (SPOG) Swiss National Cohort (SNC) Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
description	<h4>Background</h4>To date, few risk factors for childhood acute lymphoblastic leukemia (ALL) have been confirmed and the scientific literature is full of controversial "evidence." We examined if family characteristics, particularly maternal and paternal age and number of older siblings, were risk factors for childhood acute lymphoblastic leukemia (ALL).<h4>Methodology/principal findings</h4>In this population-based nationwide matched case-control study, patients 0-14 years of age with ALL diagnosed 1991-2006 and registered in the Swiss Childhood Cancer Registry were linked with their census records of 1990 and 2000. Eight controls per case were selected from the census. The association between family characteristics and ALL was analyzed by conditional logistic regressions. We found that increasing maternal age was associated with incidence of ALL in the offspring (OR per 5-year increase in maternal age 1.18, 95% CI 1.05-1.31; p = 0.004), remaining stable (trend OR 1.14, 95% CI 0.99-1.31; p = 0.060) after adjustment for other risk factors. The association with paternal age was weaker (OR per 5-year increase 1.14, 95% CI 1.01-1.28, p = 0.032) and disappeared after adjustments. Number of older siblings was not associated with risk of ALL in the overall group of children aged 0-14 years at diagnosis. However, we found a negative trend between number of older siblings and ALL diagnosed at age 0-4 years (OR per sibling 0.85, 95% CI 0.68-1.06; p = 0.141) and a positive trend for ALL diagnosed at age 5-9 (OR 1.34, 95% CI 1.05-1.72; p = 0.019), with some evidence for an effect modification (p-value for interaction = 0.040).<h4>Conclusions</h4>As in other studies, increasing maternal, but not paternal age was associated with risk of ALL. We found only a weak association with the number of older siblings, suggesting a delay in disease manifestation rather than a decrease in incidence.
format	article
author	Martin Feller Martin Adam Marcel Zwahlen Pierluigi Brazzola Felix Niggli Claudia Kuehni Swiss Pediatric Oncology Group (SPOG) Swiss National Cohort (SNC)
author_facet	Martin Feller Martin Adam Marcel Zwahlen Pierluigi Brazzola Felix Niggli Claudia Kuehni Swiss Pediatric Oncology Group (SPOG) Swiss National Cohort (SNC)
author_sort	Martin Feller
title	Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
title_short	Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
title_full	Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
title_fullStr	Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
title_full_unstemmed	Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
title_sort	family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/1d4b5ea447934776979b65c046647a65
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Family characteristics as risk factors for childhood acute lymphoblastic leukemia: a population-based case-control study.

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