White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study

The present study was designed to systemically evaluate changes in the diffusion tensor imaging (DTI)-derived parameters of iNPH (idiopathic normal pressure hydrocephalus) patients with different responses to the tap test (TT), and to correlate cognitive impairment with white matter (WM) degeneratio...

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Autores principales:	Yufeng Tang, Xiaoqin Yuan, Jinfeng Duan, Xianwen Zhang, Jiao Chen, Ying Zhou, Fangzhou Song, Dong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	idiopathic normal pressure hydrocephalus (iNPH) tap test diffusion tensor imaging tract-based spatial statistics (TBSS) cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1d4de38e2fa842fcb02fc59a072cd39c
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spelling	oai:doaj.org-article:1d4de38e2fa842fcb02fc59a072cd39c2021-12-03T05:34:32ZWhite Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study1662-453X10.3389/fnins.2021.774638https://doaj.org/article/1d4de38e2fa842fcb02fc59a072cd39c2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.774638/fullhttps://doaj.org/toc/1662-453XThe present study was designed to systemically evaluate changes in the diffusion tensor imaging (DTI)-derived parameters of iNPH (idiopathic normal pressure hydrocephalus) patients with different responses to the tap test (TT), and to correlate cognitive impairment with white matter (WM) degeneration. This study included 22 iNPH patients and 14 healthy controls with structural magnetic resonance imaging (MRI) and DTI scanning. DTI was used to explore the differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for all participants. DTI parameters were evaluated using an ROI (region of interest)-based and tract-based spatial statistics (TBSS) approach. Neuropsychological assessments and the idiopathic normal pressure hydrocephalus grading scoring scale (iNPHGS) were performed. Compared to the TT non-responders, the TT responders group had significantly lower FA values in the corpus callosum, cingulum cingulate gyrus, superior longitudinal fasciculus, and lower AD values in the right cingulum cingulate gyrus and the left posterior thalamic radiation. Besides, the MD values were significantly increased in the corpus callosum, left anterior corona radiata, and the RD values in the corpus callosum and cingulum cingulate gyrus. In addition, the cognitive improvement was negatively correlated with FA of the corpus callosum, cingulum cingulate gyrus, and MD values of the genu of corpus callosum. While, the cognitive improvement was positively related to the AD of the cingulum cingulate gyrus, superior longitudinal, and RD values of the corpus callosum, cingulum cingulate gyrus and uncinate fasciculus. The ROI specific WM lesions in iNPH patients are the underlying basis for cognitive impairment.Yufeng TangXiaoqin YuanJinfeng DuanXianwen ZhangJiao ChenYing ZhouFangzhou SongDong ZhouFrontiers Media S.A.articleidiopathic normal pressure hydrocephalus (iNPH)tap testdiffusion tensor imagingtract-based spatial statistics (TBSS)cognitive impairmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic normal pressure hydrocephalus (iNPH) tap test diffusion tensor imaging tract-based spatial statistics (TBSS) cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	idiopathic normal pressure hydrocephalus (iNPH) tap test diffusion tensor imaging tract-based spatial statistics (TBSS) cognitive impairment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Yufeng Tang Xiaoqin Yuan Jinfeng Duan Xianwen Zhang Jiao Chen Ying Zhou Fangzhou Song Dong Zhou White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study
description	The present study was designed to systemically evaluate changes in the diffusion tensor imaging (DTI)-derived parameters of iNPH (idiopathic normal pressure hydrocephalus) patients with different responses to the tap test (TT), and to correlate cognitive impairment with white matter (WM) degeneration. This study included 22 iNPH patients and 14 healthy controls with structural magnetic resonance imaging (MRI) and DTI scanning. DTI was used to explore the differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) for all participants. DTI parameters were evaluated using an ROI (region of interest)-based and tract-based spatial statistics (TBSS) approach. Neuropsychological assessments and the idiopathic normal pressure hydrocephalus grading scoring scale (iNPHGS) were performed. Compared to the TT non-responders, the TT responders group had significantly lower FA values in the corpus callosum, cingulum cingulate gyrus, superior longitudinal fasciculus, and lower AD values in the right cingulum cingulate gyrus and the left posterior thalamic radiation. Besides, the MD values were significantly increased in the corpus callosum, left anterior corona radiata, and the RD values in the corpus callosum and cingulum cingulate gyrus. In addition, the cognitive improvement was negatively correlated with FA of the corpus callosum, cingulum cingulate gyrus, and MD values of the genu of corpus callosum. While, the cognitive improvement was positively related to the AD of the cingulum cingulate gyrus, superior longitudinal, and RD values of the corpus callosum, cingulum cingulate gyrus and uncinate fasciculus. The ROI specific WM lesions in iNPH patients are the underlying basis for cognitive impairment.
format	article
author	Yufeng Tang Xiaoqin Yuan Jinfeng Duan Xianwen Zhang Jiao Chen Ying Zhou Fangzhou Song Dong Zhou
author_facet	Yufeng Tang Xiaoqin Yuan Jinfeng Duan Xianwen Zhang Jiao Chen Ying Zhou Fangzhou Song Dong Zhou
author_sort	Yufeng Tang
title	White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study
title_short	White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study
title_full	White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study
title_fullStr	White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study
title_full_unstemmed	White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study
title_sort	white matter characteristics of cognitive impairment in tap-test positive idiopathic normal pressure hydrocephalus: a diffusion tensor tract-based spatial study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1d4de38e2fa842fcb02fc59a072cd39c
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White Matter Characteristics of Cognitive Impairment in Tap-Test Positive Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Study

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