$Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states$
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Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and suggest a mechanism by which the two cytokines can syn...

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Autores principales:	Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e
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spelling	oai:doaj.org-article:1d4f418033bb45d7b771ae8b6ba8118e2021-12-02T16:57:39ZSignal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states10.1038/ncomms120572041-1723https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12057https://doaj.org/toc/2041-1723In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and suggest a mechanism by which the two cytokines can synergistically modulate inflammation.Antony AdamsonChristopher BoddingtonPolly DowntonWilliam RoweJames BagnallConnie LamApolinar Maya-MendozaLorraine SchmidtClaire V. HarperDavid G. SpillerDavid A. RandDean A. JacksonMichael R. H. WhitePawel PaszekNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antony Adamson Christopher Boddington Polly Downton William Rowe James Bagnall Connie Lam Apolinar Maya-Mendoza Lorraine Schmidt Claire V. Harper David G. Spiller David A. Rand Dean A. Jackson Michael R. H. White Pawel Paszek Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
description	In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and suggest a mechanism by which the two cytokines can synergistically modulate inflammation.
format	article
author	Antony Adamson Christopher Boddington Polly Downton William Rowe James Bagnall Connie Lam Apolinar Maya-Mendoza Lorraine Schmidt Claire V. Harper David G. Spiller David A. Rand Dean A. Jackson Michael R. H. White Pawel Paszek
author_facet	Antony Adamson Christopher Boddington Polly Downton William Rowe James Bagnall Connie Lam Apolinar Maya-Mendoza Lorraine Schmidt Claire V. Harper David G. Spiller David A. Rand Dean A. Jackson Michael R. H. White Pawel Paszek
author_sort	Antony Adamson
title	Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
title_short	Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
title_full	Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
title_fullStr	Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
title_full_unstemmed	Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states
title_sort	signal transduction controls heterogeneous nf-κb dynamics and target gene expression through cytokine-specific refractory states
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e
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_version_	1718382489071779840

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

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