Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.

Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described. The staphylococcal proteins surface immunoglobulin-binding pr...

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Autores principales:	Tina K Koch, Michael Reuter, Diana Barthel, Sascha Böhm, Jean van den Elsen, Peter Kraiczy, Peter F Zipfel, Christine Skerka
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d50121184b64c4da55edbbaa7da09d5
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spelling	oai:doaj.org-article:1d50121184b64c4da55edbbaa7da09d52021-11-18T08:12:17ZStaphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.1932-620310.1371/journal.pone.0047638https://doaj.org/article/1d50121184b64c4da55edbbaa7da09d52012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071827/?tool=EBIhttps://doaj.org/toc/1932-6203Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described. The staphylococcal proteins surface immunoglobulin-binding protein (Sbi) and extracellular fibrinogen-binding protein (Efb) bind C3/C3b simultaneously with plasminogen. Bound plasminogen is converted by bacterial activator staphylokinase or by host-specific urokinase-type plasminogen activator to plasmin, which in turn leads to degradation of complement C3 and C3b. Efb and to a lesser extend Sbi enhance plasmin cleavage of C3/C3b, an effect which is explained by a conformational change in C3/C3b induced by Sbi and Efb. Furthermore, bound plasmin also degrades C3a, which exerts anaphylatoxic and antimicrobial activities. Thus, S. aureus Sbi and Efb comprise platforms to recruit plasmin(ogen) together with C3 and its activation product C3b for efficient degradation of these complement components in the local microbial environment and to protect S. aureus from host innate immune reactions.Tina K KochMichael ReuterDiana BarthelSascha BöhmJean van den ElsenPeter KraiczyPeter F ZipfelChristine SkerkaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47638 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tina K Koch Michael Reuter Diana Barthel Sascha Böhm Jean van den Elsen Peter Kraiczy Peter F Zipfel Christine Skerka Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
description	Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described. The staphylococcal proteins surface immunoglobulin-binding protein (Sbi) and extracellular fibrinogen-binding protein (Efb) bind C3/C3b simultaneously with plasminogen. Bound plasminogen is converted by bacterial activator staphylokinase or by host-specific urokinase-type plasminogen activator to plasmin, which in turn leads to degradation of complement C3 and C3b. Efb and to a lesser extend Sbi enhance plasmin cleavage of C3/C3b, an effect which is explained by a conformational change in C3/C3b induced by Sbi and Efb. Furthermore, bound plasmin also degrades C3a, which exerts anaphylatoxic and antimicrobial activities. Thus, S. aureus Sbi and Efb comprise platforms to recruit plasmin(ogen) together with C3 and its activation product C3b for efficient degradation of these complement components in the local microbial environment and to protect S. aureus from host innate immune reactions.
format	article
author	Tina K Koch Michael Reuter Diana Barthel Sascha Böhm Jean van den Elsen Peter Kraiczy Peter F Zipfel Christine Skerka
author_facet	Tina K Koch Michael Reuter Diana Barthel Sascha Böhm Jean van den Elsen Peter Kraiczy Peter F Zipfel Christine Skerka
author_sort	Tina K Koch
title	Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
title_short	Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
title_full	Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
title_fullStr	Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
title_full_unstemmed	Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.
title_sort	staphylococcus aureus proteins sbi and efb recruit human plasmin to degrade complement c3 and c3b.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1d50121184b64c4da55edbbaa7da09d5
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Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.

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