NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation
NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al. identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification.
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Nature Portfolio
2016
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| Acceso en línea: | https://doaj.org/article/1d59b48eca8c4a3bbdb4c8ba16338986 |
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oai:doaj.org-article:1d59b48eca8c4a3bbdb4c8ba163389862021-12-02T14:38:55ZNMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation10.1038/ncomms112642041-1723https://doaj.org/article/1d59b48eca8c4a3bbdb4c8ba163389862016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11264https://doaj.org/toc/2041-1723NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al. identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification.René A. W. FrankNoboru H. KomiyamaTomás J. RyanFei ZhuThomas J. O’DellSeth G. N. GrantNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q René A. W. Frank Noboru H. Komiyama Tomás J. Ryan Fei Zhu Thomas J. O’Dell Seth G. N. Grant NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| description |
NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al. identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification. |
| format |
article |
| author |
René A. W. Frank Noboru H. Komiyama Tomás J. Ryan Fei Zhu Thomas J. O’Dell Seth G. N. Grant |
| author_facet |
René A. W. Frank Noboru H. Komiyama Tomás J. Ryan Fei Zhu Thomas J. O’Dell Seth G. N. Grant |
| author_sort |
René A. W. Frank |
| title |
NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| title_short |
NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| title_full |
NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| title_fullStr |
NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| title_full_unstemmed |
NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| title_sort |
nmda receptors are selectively partitioned into complexes and supercomplexes during synapse maturation |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/1d59b48eca8c4a3bbdb4c8ba16338986 |
| work_keys_str_mv |
AT reneawfrank nmdareceptorsareselectivelypartitionedintocomplexesandsupercomplexesduringsynapsematuration AT noboruhkomiyama nmdareceptorsareselectivelypartitionedintocomplexesandsupercomplexesduringsynapsematuration AT tomasjryan nmdareceptorsareselectivelypartitionedintocomplexesandsupercomplexesduringsynapsematuration AT feizhu nmdareceptorsareselectivelypartitionedintocomplexesandsupercomplexesduringsynapsematuration AT thomasjodell nmdareceptorsareselectivelypartitionedintocomplexesandsupercomplexesduringsynapsematuration AT sethgngrant nmdareceptorsareselectivelypartitionedintocomplexesandsupercomplexesduringsynapsematuration |
| _version_ |
1718390817054261248 |