Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis

Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis

Hyo-Jeong Lee,1 Jakkid Sanetuntikul,2 Eun-Sook Choi,1 Bo Ram Lee,1 Jung-Hee Kim,1 Eunjoo Kim,1 Sangaraju Shanmugam2 1Nano and Bio Research Division, 2Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Abstract: We describe here a...

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Autores principales: Lee HJ, Sanetuntikul J, Choi ES, Lee BR, Kim JH, Kim E, Shanmugam S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/1d5b33cfc24945bea1f2456183117e13
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spelling oai:doaj.org-article:1d5b33cfc24945bea1f2456183117e132021-12-02T05:10:43ZPhotothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis1178-2013https://doaj.org/article/1d5b33cfc24945bea1f2456183117e132014-12-01T00:00:00Zhttp://www.dovepress.com/photothermal-cancer-therapy-using-graphitic-carbonndashcoated-magnetic-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Hyo-Jeong Lee,1 Jakkid Sanetuntikul,2 Eun-Sook Choi,1 Bo Ram Lee,1 Jung-Hee Kim,1 Eunjoo Kim,1 Sangaraju Shanmugam2 1Nano and Bio Research Division, 2Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Abstract: We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C) particles using a single-component precursor, iron (III) diethylenetriaminepentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light), the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm-2). These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. Keywords: graphitic carbon–encapsulated magnetic nanoparticles, iron oxide, one-pot synthesis, photothermal cancer therapyLee HJSanetuntikul JChoi ESLee BRKim JHKim EShanmugam SDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 271-282 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Lee HJ
Sanetuntikul J
Choi ES
Lee BR
Kim JH
Kim E
Shanmugam S
Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
description Hyo-Jeong Lee,1 Jakkid Sanetuntikul,2 Eun-Sook Choi,1 Bo Ram Lee,1 Jung-Hee Kim,1 Eunjoo Kim,1 Sangaraju Shanmugam2 1Nano and Bio Research Division, 2Department of Energy Systems Engineering, Daegu Gyeongbuk Institute of Science and Technology, Daegu, Republic of Korea Abstract: We describe here a simple synthetic strategy for the fabrication of carbon-coated Fe3O4 (Fe3O4@C) particles using a single-component precursor, iron (III) diethylenetriaminepentaacetic acid complex. Physicochemical analyses revealed that the core of the synthesized particles consists of ferromagnetic Fe3O4 material ranging several hundred nanometers, embedded in nitrogen-doped graphitic carbon with a thickness of ~120 nm. Because of their photothermal activity (absorption of near-infrared [NIR] light), the Fe3O4@C particles have been investigated for photothermal therapeutic applications. An example of one such application would be the use of Fe3O4@C particles in human adenocarcinoma A549 cells by means of NIR-triggered cell death. In this system, the Fe3O4@C can rapidly generate heat, causing >98% cell death within 10 minutes under 808 nm NIR laser irradiation (2.3 W cm-2). These Fe3O4@C particles provided a superior photothermal therapeutic effect by intratumoral delivery and NIR irradiation of tumor xenografts. These results demonstrate that one-pot synthesis of carbon-coated magnetic particles could provide promising materials for future clinical applications and encourage further investigation of this simple method. Keywords: graphitic carbon–encapsulated magnetic nanoparticles, iron oxide, one-pot synthesis, photothermal cancer therapy
format article
author Lee HJ
Sanetuntikul J
Choi ES
Lee BR
Kim JH
Kim E
Shanmugam S
author_facet Lee HJ
Sanetuntikul J
Choi ES
Lee BR
Kim JH
Kim E
Shanmugam S
author_sort Lee HJ
title Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
title_short Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
title_full Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
title_fullStr Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
title_full_unstemmed Photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
title_sort photothermal cancer therapy using graphitic carbon–coated magnetic particles prepared by one-pot synthesis
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/1d5b33cfc24945bea1f2456183117e13
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AT choies photothermalcancertherapyusinggraphiticcarbonndashcoatedmagneticparticlespreparedbynbsponepotsynthesis
AT leebr photothermalcancertherapyusinggraphiticcarbonndashcoatedmagneticparticlespreparedbynbsponepotsynthesis
AT kimjh photothermalcancertherapyusinggraphiticcarbonndashcoatedmagneticparticlespreparedbynbsponepotsynthesis
AT kime photothermalcancertherapyusinggraphiticcarbonndashcoatedmagneticparticlespreparedbynbsponepotsynthesis
AT shanmugams photothermalcancertherapyusinggraphiticcarbonndashcoatedmagneticparticlespreparedbynbsponepotsynthesis
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