Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.

To further extend our understanding of the mechanism causing the current nearly extinct status of the baiji (Lipotes vexillifer), one of the most critically endangered species in the world, genetic diversity at the major histocompatibility complex (MHC) class II DRB locus was investigated in the bai...

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Autores principales:	Shixia Xu, Jianfeng Ju, Xuming Zhou, Lian Wang, Kaiya Zhou, Guang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d5c5cdf593f474e979f06d27512db46
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spelling	oai:doaj.org-article:1d5c5cdf593f474e979f06d27512db462021-11-18T07:30:02ZConsiderable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.1932-620310.1371/journal.pone.0030423https://doaj.org/article/1d5c5cdf593f474e979f06d27512db462012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22272349/?tool=EBIhttps://doaj.org/toc/1932-6203To further extend our understanding of the mechanism causing the current nearly extinct status of the baiji (Lipotes vexillifer), one of the most critically endangered species in the world, genetic diversity at the major histocompatibility complex (MHC) class II DRB locus was investigated in the baiji. Nine highly divergent DRB alleles were identified in 17 samples, with an average of 28.4 (13.2%) nucleotide difference and 16.7 (23.5%) amino acid difference between alleles. The unexpectedly high levels of DRB allelic diversity in the baiji may partly be attributable to its evolutionary adaptations to the freshwater environment which is regarded to have a higher parasite diversity compared to the marine environment. In addition, balancing selection was found to be the main mechanisms in generating sequence diversity at baiji DRB gene. Considerable sequence variation at the adaptive MHC genes despite of significant loss of neutral genetic variation in baiji genome might suggest that intense selection has overpowered random genetic drift as the main evolutionary forces, which further suggested that the critically endangered or nearly extinct status of the baiji is not an outcome of genetic collapse.Shixia XuJianfeng JuXuming ZhouLian WangKaiya ZhouGuang YangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30423 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shixia Xu Jianfeng Ju Xuming Zhou Lian Wang Kaiya Zhou Guang Yang Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
description	To further extend our understanding of the mechanism causing the current nearly extinct status of the baiji (Lipotes vexillifer), one of the most critically endangered species in the world, genetic diversity at the major histocompatibility complex (MHC) class II DRB locus was investigated in the baiji. Nine highly divergent DRB alleles were identified in 17 samples, with an average of 28.4 (13.2%) nucleotide difference and 16.7 (23.5%) amino acid difference between alleles. The unexpectedly high levels of DRB allelic diversity in the baiji may partly be attributable to its evolutionary adaptations to the freshwater environment which is regarded to have a higher parasite diversity compared to the marine environment. In addition, balancing selection was found to be the main mechanisms in generating sequence diversity at baiji DRB gene. Considerable sequence variation at the adaptive MHC genes despite of significant loss of neutral genetic variation in baiji genome might suggest that intense selection has overpowered random genetic drift as the main evolutionary forces, which further suggested that the critically endangered or nearly extinct status of the baiji is not an outcome of genetic collapse.
format	article
author	Shixia Xu Jianfeng Ju Xuming Zhou Lian Wang Kaiya Zhou Guang Yang
author_facet	Shixia Xu Jianfeng Ju Xuming Zhou Lian Wang Kaiya Zhou Guang Yang
author_sort	Shixia Xu
title	Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
title_short	Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
title_full	Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
title_fullStr	Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
title_full_unstemmed	Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
title_sort	considerable mhc diversity suggests that the functional extinction of baiji is not related to population genetic collapse.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1d5c5cdf593f474e979f06d27512db46
work_keys_str_mv	AT shixiaxu considerablemhcdiversitysuggeststhatthefunctionalextinctionofbaijiisnotrelatedtopopulationgeneticcollapse AT jianfengju considerablemhcdiversitysuggeststhatthefunctionalextinctionofbaijiisnotrelatedtopopulationgeneticcollapse AT xumingzhou considerablemhcdiversitysuggeststhatthefunctionalextinctionofbaijiisnotrelatedtopopulationgeneticcollapse AT lianwang considerablemhcdiversitysuggeststhatthefunctionalextinctionofbaijiisnotrelatedtopopulationgeneticcollapse AT kaiyazhou considerablemhcdiversitysuggeststhatthefunctionalextinctionofbaijiisnotrelatedtopopulationgeneticcollapse AT guangyang considerablemhcdiversitysuggeststhatthefunctionalextinctionofbaijiisnotrelatedtopopulationgeneticcollapse
_version_	1718423334025166848

Considerable MHC diversity suggests that the functional extinction of baiji is not related to population genetic collapse.

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