Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.
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Nature Portfolio
2019
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oai:doaj.org-article:1d5dfae220234a1b8cf7ca069a554a2a2021-12-02T14:40:00ZMutant p53 drives clonal hematopoiesis through modulating epigenetic pathway10.1038/s41467-019-13542-22041-1723https://doaj.org/article/1d5dfae220234a1b8cf7ca069a554a2a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13542-2https://doaj.org/toc/2041-1723Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.Sisi ChenQiang WangHao YuMaegan L. CapitanoSasidhar VemulaSarah C. NabingerRui GaoChonghua YaoMichihiro KobayashiZhuangzhuang GengAidan FaheyDanielle HenleyStephen Z. LiuSergio BarajasWenjie CaiEric R. WolfBaskar RamdasZhigang CaiHongyu GaoNa LuoYang SunTerrence N. WongDaniel C. LinkYunlong LiuH. Scott BoswellLindsey D. MayoGang HuangReuben KapurMervin C. YoderHal E. BroxmeyerZhonghua GaoYan LiuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Sisi Chen Qiang Wang Hao Yu Maegan L. Capitano Sasidhar Vemula Sarah C. Nabinger Rui Gao Chonghua Yao Michihiro Kobayashi Zhuangzhuang Geng Aidan Fahey Danielle Henley Stephen Z. Liu Sergio Barajas Wenjie Cai Eric R. Wolf Baskar Ramdas Zhigang Cai Hongyu Gao Na Luo Yang Sun Terrence N. Wong Daniel C. Link Yunlong Liu H. Scott Boswell Lindsey D. Mayo Gang Huang Reuben Kapur Mervin C. Yoder Hal E. Broxmeyer Zhonghua Gao Yan Liu Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| description |
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2. |
| format |
article |
| author |
Sisi Chen Qiang Wang Hao Yu Maegan L. Capitano Sasidhar Vemula Sarah C. Nabinger Rui Gao Chonghua Yao Michihiro Kobayashi Zhuangzhuang Geng Aidan Fahey Danielle Henley Stephen Z. Liu Sergio Barajas Wenjie Cai Eric R. Wolf Baskar Ramdas Zhigang Cai Hongyu Gao Na Luo Yang Sun Terrence N. Wong Daniel C. Link Yunlong Liu H. Scott Boswell Lindsey D. Mayo Gang Huang Reuben Kapur Mervin C. Yoder Hal E. Broxmeyer Zhonghua Gao Yan Liu |
| author_facet |
Sisi Chen Qiang Wang Hao Yu Maegan L. Capitano Sasidhar Vemula Sarah C. Nabinger Rui Gao Chonghua Yao Michihiro Kobayashi Zhuangzhuang Geng Aidan Fahey Danielle Henley Stephen Z. Liu Sergio Barajas Wenjie Cai Eric R. Wolf Baskar Ramdas Zhigang Cai Hongyu Gao Na Luo Yang Sun Terrence N. Wong Daniel C. Link Yunlong Liu H. Scott Boswell Lindsey D. Mayo Gang Huang Reuben Kapur Mervin C. Yoder Hal E. Broxmeyer Zhonghua Gao Yan Liu |
| author_sort |
Sisi Chen |
| title |
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| title_short |
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| title_full |
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| title_fullStr |
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| title_full_unstemmed |
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| title_sort |
mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/1d5dfae220234a1b8cf7ca069a554a2a |
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