Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar

Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may contribute to axonal regrow. Over the past few decades, studies have found that the interaction between immune cells...

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Autores principales:	Qi-Ming Pang, Si-Yu Chen, Qi-Jing Xu, Sheng-Ping Fu, Yi-Chun Yang, Wang-Hui Zou, Meng Zhang, Juan Liu, Wei-Hong Wan, Jia-Chen Peng, Tao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	spinal cord injury mesenchymal stem cells astrocyte T cells macrophage neuroinflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1d5f7a56172f4e938b660ea32aed6a10
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spelling	oai:doaj.org-article:1d5f7a56172f4e938b660ea32aed6a102021-12-02T08:56:46ZNeuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar1664-322410.3389/fimmu.2021.751021https://doaj.org/article/1d5f7a56172f4e938b660ea32aed6a102021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.751021/fullhttps://doaj.org/toc/1664-3224Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may contribute to axonal regrow. Over the past few decades, studies have found that the interaction between immune cells at the damaged site results in a robust and persistent inflammatory response. Current therapy strategies focus primarily on the inhibition of subacute and chronic neuroinflammation after the acute inflammatory response was executed. Growing evidences have documented that mesenchymal stem cells (MSCs) engraftment can be served as a promising cell therapy for SCI. Numerous studies have shown that MSCs transplantation can inhibit the excessive glial scar formation as well as inflammatory response, thereby facilitating the anatomical and functional recovery. Here, we will review the effects of inflammatory response and glial scar formation in spinal cord injury and repair. The role of MSCs in regulating neuroinflammation and glial scar formation after SCI will be reviewed as well.Qi-Ming PangQi-Ming PangSi-Yu ChenQi-Jing XuSheng-Ping FuSheng-Ping FuYi-Chun YangWang-Hui ZouMeng ZhangJuan LiuWei-Hong WanJia-Chen PengTao ZhangFrontiers Media S.A.articlespinal cord injurymesenchymal stem cellsastrocyteT cellsmacrophageneuroinflammationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal cord injury mesenchymal stem cells astrocyte T cells macrophage neuroinflammation Immunologic diseases. Allergy RC581-607
spellingShingle	spinal cord injury mesenchymal stem cells astrocyte T cells macrophage neuroinflammation Immunologic diseases. Allergy RC581-607 Qi-Ming Pang Qi-Ming Pang Si-Yu Chen Qi-Jing Xu Sheng-Ping Fu Sheng-Ping Fu Yi-Chun Yang Wang-Hui Zou Meng Zhang Juan Liu Wei-Hong Wan Jia-Chen Peng Tao Zhang Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
description	Transected axons are unable to regenerate after spinal cord injury (SCI). Glial scar is thought to be responsible for this failure. Regulating the formation of glial scar post-SCI may contribute to axonal regrow. Over the past few decades, studies have found that the interaction between immune cells at the damaged site results in a robust and persistent inflammatory response. Current therapy strategies focus primarily on the inhibition of subacute and chronic neuroinflammation after the acute inflammatory response was executed. Growing evidences have documented that mesenchymal stem cells (MSCs) engraftment can be served as a promising cell therapy for SCI. Numerous studies have shown that MSCs transplantation can inhibit the excessive glial scar formation as well as inflammatory response, thereby facilitating the anatomical and functional recovery. Here, we will review the effects of inflammatory response and glial scar formation in spinal cord injury and repair. The role of MSCs in regulating neuroinflammation and glial scar formation after SCI will be reviewed as well.
format	article
author	Qi-Ming Pang Qi-Ming Pang Si-Yu Chen Qi-Jing Xu Sheng-Ping Fu Sheng-Ping Fu Yi-Chun Yang Wang-Hui Zou Meng Zhang Juan Liu Wei-Hong Wan Jia-Chen Peng Tao Zhang
author_facet	Qi-Ming Pang Qi-Ming Pang Si-Yu Chen Qi-Jing Xu Sheng-Ping Fu Sheng-Ping Fu Yi-Chun Yang Wang-Hui Zou Meng Zhang Juan Liu Wei-Hong Wan Jia-Chen Peng Tao Zhang
author_sort	Qi-Ming Pang
title	Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
title_short	Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
title_full	Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
title_fullStr	Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
title_full_unstemmed	Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
title_sort	neuroinflammation and scarring after spinal cord injury: therapeutic roles of mscs on inflammation and glial scar
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1d5f7a56172f4e938b660ea32aed6a10
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Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar

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