P2X7 receptor antagonism modulates IL-1β and MMP9 in human atherosclerotic vessels

P2X7 receptor antagonism modulates IL-1β and MMP9 in human atherosclerotic vessels

Abstract In atherosclerosis, matrix metallopeptidases (MMPs) contribute to plaque rupture through weakening of the fibrous cap. Pleiotropic P2X purinoceptor 7 (P2X7), expressed in the carotid plaque (PL), is involved in interleukin 1 beta (IL-1β) release that may influence MMP9 generation, thus thei...

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Autores principales: Maria Lombardi, Maria Elena Mantione, Domenico Baccellieri, David Ferrara, Renata Castellano, Roberto Chiesa, Ottavio Alfieri, Chiara Foglieni
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/1d61b32b9d41497dbcd510eb4700511b
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