Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples

The study of tumour heterogeneity can be improved by sequencing multiple samples, but currently available variant callers have not been tailored to integrate them. Here the authors present Moss, a tool that can leverage multiple samples to improve somatic variant calling in different cancers.

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Autores principales:	Chuanyi Zhang, Mohammed El-Kebir, Idoia Ochoa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d662e56843240cb8dc1f2695a9295ee
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spelling	oai:doaj.org-article:1d662e56843240cb8dc1f2695a9295ee2021-12-02T15:51:06ZMoss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples10.1038/s41467-021-22466-92041-1723https://doaj.org/article/1d662e56843240cb8dc1f2695a9295ee2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22466-9https://doaj.org/toc/2041-1723The study of tumour heterogeneity can be improved by sequencing multiple samples, but currently available variant callers have not been tailored to integrate them. Here the authors present Moss, a tool that can leverage multiple samples to improve somatic variant calling in different cancers.Chuanyi ZhangMohammed El-KebirIdoia OchoaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chuanyi Zhang Mohammed El-Kebir Idoia Ochoa Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
description	The study of tumour heterogeneity can be improved by sequencing multiple samples, but currently available variant callers have not been tailored to integrate them. Here the authors present Moss, a tool that can leverage multiple samples to improve somatic variant calling in different cancers.
format	article
author	Chuanyi Zhang Mohammed El-Kebir Idoia Ochoa
author_facet	Chuanyi Zhang Mohammed El-Kebir Idoia Ochoa
author_sort	Chuanyi Zhang
title	Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
title_short	Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
title_full	Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
title_fullStr	Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
title_full_unstemmed	Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples
title_sort	moss enables high sensitivity single-nucleotide variant calling from multiple bulk dna tumor samples
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1d662e56843240cb8dc1f2695a9295ee
work_keys_str_mv	AT chuanyizhang mossenableshighsensitivitysinglenucleotidevariantcallingfrommultiplebulkdnatumorsamples AT mohammedelkebir mossenableshighsensitivitysinglenucleotidevariantcallingfrommultiplebulkdnatumorsamples AT idoiaochoa mossenableshighsensitivitysinglenucleotidevariantcallingfrommultiplebulkdnatumorsamples
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Moss enables high sensitivity single-nucleotide variant calling from multiple bulk DNA tumor samples

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