Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.

Despite great efforts to control the infection of poultry with H5N1 viruses, these pathogens continue to evolve and spread in nature, threatening public health. Elucidating the characteristics of H5N1 avian influenza virus will benefit disease control and pandemic preparation. Here, we sequenced the...

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Autores principales:	Dongming Zhao, Libin Liang, Yanbing Li, Yongping Jiang, Liling Liu, Hualan Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d6add55aa88433ba84b5f3d4ab8d1ca
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spelling	oai:doaj.org-article:1d6add55aa88433ba84b5f3d4ab8d1ca2021-11-18T08:06:37ZPhylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.1932-620310.1371/journal.pone.0050959https://doaj.org/article/1d6add55aa88433ba84b5f3d4ab8d1ca2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23226433/?tool=EBIhttps://doaj.org/toc/1932-6203Despite great efforts to control the infection of poultry with H5N1 viruses, these pathogens continue to evolve and spread in nature, threatening public health. Elucidating the characteristics of H5N1 avian influenza virus will benefit disease control and pandemic preparation. Here, we sequenced the genomes of 15 H5N1 avian influenza viruses isolated in Vietnam in 2006 and 2007 and performed phylogenetic analyses to compare these sequences with those of other viruses available in the public databases. Molecular characterization of the H5N1 viruses revealed that seven genetically distinct clades of H5N1 viruses have appeared in Vietnam. Clade 2.3.4 viruses existed in Vietnam as early as 2005. Fifteen viruses isolated during 2006 and 2007 belonged to clade 1 and clade 2.3.4, and were divided into five genotypes. Reassortants between the clade 1 and clade 2.3.4 viruses were detected in both North and South Vietnam. We also assessed the replication and pathogenicity of these viruses in mice and found that these isolates replicated efficiently and exhibited distinct virulence in mice. Our results provide important information regarding the diversity of H5N1 viruses in nature.Dongming ZhaoLibin LiangYanbing LiYongping JiangLiling LiuHualan ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e50959 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dongming Zhao Libin Liang Yanbing Li Yongping Jiang Liling Liu Hualan Chen Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.
description	Despite great efforts to control the infection of poultry with H5N1 viruses, these pathogens continue to evolve and spread in nature, threatening public health. Elucidating the characteristics of H5N1 avian influenza virus will benefit disease control and pandemic preparation. Here, we sequenced the genomes of 15 H5N1 avian influenza viruses isolated in Vietnam in 2006 and 2007 and performed phylogenetic analyses to compare these sequences with those of other viruses available in the public databases. Molecular characterization of the H5N1 viruses revealed that seven genetically distinct clades of H5N1 viruses have appeared in Vietnam. Clade 2.3.4 viruses existed in Vietnam as early as 2005. Fifteen viruses isolated during 2006 and 2007 belonged to clade 1 and clade 2.3.4, and were divided into five genotypes. Reassortants between the clade 1 and clade 2.3.4 viruses were detected in both North and South Vietnam. We also assessed the replication and pathogenicity of these viruses in mice and found that these isolates replicated efficiently and exhibited distinct virulence in mice. Our results provide important information regarding the diversity of H5N1 viruses in nature.
format	article
author	Dongming Zhao Libin Liang Yanbing Li Yongping Jiang Liling Liu Hualan Chen
author_facet	Dongming Zhao Libin Liang Yanbing Li Yongping Jiang Liling Liu Hualan Chen
author_sort	Dongming Zhao
title	Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.
title_short	Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.
title_full	Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.
title_fullStr	Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.
title_full_unstemmed	Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.
title_sort	phylogenetic and pathogenic analyses of avian influenza a h5n1 viruses isolated from poultry in vietnam.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1d6add55aa88433ba84b5f3d4ab8d1ca
work_keys_str_mv	AT dongmingzhao phylogeneticandpathogenicanalysesofavianinfluenzaah5n1virusesisolatedfrompoultryinvietnam AT libinliang phylogeneticandpathogenicanalysesofavianinfluenzaah5n1virusesisolatedfrompoultryinvietnam AT yanbingli phylogeneticandpathogenicanalysesofavianinfluenzaah5n1virusesisolatedfrompoultryinvietnam AT yongpingjiang phylogeneticandpathogenicanalysesofavianinfluenzaah5n1virusesisolatedfrompoultryinvietnam AT lilingliu phylogeneticandpathogenicanalysesofavianinfluenzaah5n1virusesisolatedfrompoultryinvietnam AT hualanchen phylogeneticandpathogenicanalysesofavianinfluenzaah5n1virusesisolatedfrompoultryinvietnam
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Phylogenetic and pathogenic analyses of avian influenza A H5N1 viruses isolated from poultry in Vietnam.

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