BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

TLR9 is highly expressed by plasmacytoid dendritic cells and detects nucleic acids, but to discriminate between host and microbial nucleic acids TLR9 is sorted into different endosomal compartments. Here the authors show that BAD-LAMP limits type 1 interferon responses by sorting TLR9 to late endoso...

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Autores principales:	Alexis Combes, Voahirana Camosseto, Prudence N’Guessan, Rafael J. Argüello, Julie Mussard, Christophe Caux, Nathalie Bendriss-Vermare, Philippe Pierre, Evelina Gatti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d6cff0577074329b82bd699be376c33
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spelling	oai:doaj.org-article:1d6cff0577074329b82bd699be376c332021-12-02T17:01:17ZBAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells10.1038/s41467-017-00695-12041-1723https://doaj.org/article/1d6cff0577074329b82bd699be376c332017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00695-1https://doaj.org/toc/2041-1723TLR9 is highly expressed by plasmacytoid dendritic cells and detects nucleic acids, but to discriminate between host and microbial nucleic acids TLR9 is sorted into different endosomal compartments. Here the authors show that BAD-LAMP limits type 1 interferon responses by sorting TLR9 to late endosomal compartments.Alexis CombesVoahirana CamossetoPrudence N’GuessanRafael J. ArgüelloJulie MussardChristophe CauxNathalie Bendriss-VermarePhilippe PierreEvelina GattiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexis Combes Voahirana Camosseto Prudence N’Guessan Rafael J. Argüello Julie Mussard Christophe Caux Nathalie Bendriss-Vermare Philippe Pierre Evelina Gatti BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
description	TLR9 is highly expressed by plasmacytoid dendritic cells and detects nucleic acids, but to discriminate between host and microbial nucleic acids TLR9 is sorted into different endosomal compartments. Here the authors show that BAD-LAMP limits type 1 interferon responses by sorting TLR9 to late endosomal compartments.
format	article
author	Alexis Combes Voahirana Camosseto Prudence N’Guessan Rafael J. Argüello Julie Mussard Christophe Caux Nathalie Bendriss-Vermare Philippe Pierre Evelina Gatti
author_facet	Alexis Combes Voahirana Camosseto Prudence N’Guessan Rafael J. Argüello Julie Mussard Christophe Caux Nathalie Bendriss-Vermare Philippe Pierre Evelina Gatti
author_sort	Alexis Combes
title	BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
title_short	BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
title_full	BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
title_fullStr	BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
title_full_unstemmed	BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
title_sort	bad-lamp controls tlr9 trafficking and signalling in human plasmacytoid dendritic cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1d6cff0577074329b82bd699be376c33
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BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

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