Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?

ABSTRACT Vector-borne infections begin in the dermis when a pathogen is introduced by an arthropod during a blood meal. Several barriers separate an invading pathogen from its replicative niche, including phagocytic cells in the dermis that activate immunity by engulfing would-be pathogens and migra...

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Autores principales:	David M. Bland, Deborah M. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1d6d40a7cdf44cef8ca7996fd280d199
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spelling	oai:doaj.org-article:1d6d40a7cdf44cef8ca7996fd280d1992021-11-15T15:42:32ZImaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?10.1128/mBio.00837-132150-7511https://doaj.org/article/1d6d40a7cdf44cef8ca7996fd280d1992013-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00837-13https://doaj.org/toc/2150-7511ABSTRACT Vector-borne infections begin in the dermis when a pathogen is introduced by an arthropod during a blood meal. Several barriers separate an invading pathogen from its replicative niche, including phagocytic cells in the dermis that activate immunity by engulfing would-be pathogens and migrating to the lymph node. In addition, neutrophils circulating in the blood are rapidly recruited when the dermal barriers are penetrated. For flea-borne disease, no insect-encoded immune-suppressive molecules have yet been described that might influence the establishment of infection, leaving the bacteria on their own to defend against the mammalian immune system. Shortly after a flea transmits Yersinia pestis to a mammalian host, the bacteria are transported to the lymph node, where they grow logarithmically and later spread systemically. Even a single cell of Y. pestis can initiate a lethal case of plague. In their article, J. G. Shannon et al. [mBio 4(5):e00170-13, 2013, doi:10.1128/mBio.00170-13] used intravital microscopy to visualize trafficking of Y. pestis in transgenic mice in vivo, which allowed them to examine interactions between bacteria and specific immune cells. Bacteria appeared to preferentially interact with neutrophils but had no detectable interactions with dendritic cells. These findings suggest that Y. pestis infection of neutrophils not only prevents their activation but may even result in their return to circulation and migration to distal sites.David M. BlandDeborah M. AndersonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 6 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 David M. Bland Deborah M. Anderson Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?
description	ABSTRACT Vector-borne infections begin in the dermis when a pathogen is introduced by an arthropod during a blood meal. Several barriers separate an invading pathogen from its replicative niche, including phagocytic cells in the dermis that activate immunity by engulfing would-be pathogens and migrating to the lymph node. In addition, neutrophils circulating in the blood are rapidly recruited when the dermal barriers are penetrated. For flea-borne disease, no insect-encoded immune-suppressive molecules have yet been described that might influence the establishment of infection, leaving the bacteria on their own to defend against the mammalian immune system. Shortly after a flea transmits Yersinia pestis to a mammalian host, the bacteria are transported to the lymph node, where they grow logarithmically and later spread systemically. Even a single cell of Y. pestis can initiate a lethal case of plague. In their article, J. G. Shannon et al. [mBio 4(5):e00170-13, 2013, doi:10.1128/mBio.00170-13] used intravital microscopy to visualize trafficking of Y. pestis in transgenic mice in vivo, which allowed them to examine interactions between bacteria and specific immune cells. Bacteria appeared to preferentially interact with neutrophils but had no detectable interactions with dendritic cells. These findings suggest that Y. pestis infection of neutrophils not only prevents their activation but may even result in their return to circulation and migration to distal sites.
format	article
author	David M. Bland Deborah M. Anderson
author_facet	David M. Bland Deborah M. Anderson
author_sort	David M. Bland
title	Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?
title_short	Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?
title_full	Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?
title_fullStr	Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?
title_full_unstemmed	Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?
title_sort	imaging early pathogenesis of bubonic plague: are neutrophils commandeered for lymphatic transport of bacteria?
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/1d6d40a7cdf44cef8ca7996fd280d199
work_keys_str_mv	AT davidmbland imagingearlypathogenesisofbubonicplagueareneutrophilscommandeeredforlymphatictransportofbacteria AT deborahmanderson imagingearlypathogenesisofbubonicplagueareneutrophilscommandeeredforlymphatictransportofbacteria
_version_	1718427569636769792

Imaging Early Pathogenesis of Bubonic Plague: Are Neutrophils Commandeered for Lymphatic Transport of Bacteria?

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