Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy

Abstract We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthor...

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Autores principales:	Jiwon Seo, Yoo Jin Hong, Young Jin Kim, Purevjargal Lkhagvasuren, Iksung Cho, Chi Young Shim, Jong-Won Ha, Geu-Ru Hong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d7032b89add4539b28f40d0dfe6eaae
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spelling	oai:doaj.org-article:1d7032b89add4539b28f40d0dfe6eaae2021-12-02T11:57:57ZPrevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy10.1038/s41598-020-78945-42045-2322https://doaj.org/article/1d7032b89add4539b28f40d0dfe6eaae2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78945-4https://doaj.org/toc/2045-2322Abstract We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthoracic echocardiography within 6 months of each other were retrospectively analysed. RV involvement was defined as an increased RV wall thickness ≥ 7 mm on CMR in the segments of the RV free wall. Primary outcomes were defined as the composite of all-cause death, heart transplantation, and unplanned cardiovascular admission. Thirty-seven (14.4%) patients showed RV involvement. Patients with RV involvement showed a significantly higher left ventricular (LV) maximal wall thickness and left atrial volume index. Multivariate Cox model revealed that RV involvement was independently associated with primary outcomes (HR: 2.30, p = 0.024). In a subgroup analysis of patients with speckle tracking echocardiography (n = 190), those with RV involvement had significantly more impaired RV strain, which was independently associated with primary outcomes. RV involvement in patients with HCM correlated with more advanced LV structure and biventricular dysfunction, suggesting an indicator of severe HCM. RV involvement and impaired RV strain have a prognostic value related to clinical adverse events in patients with HCM.Jiwon SeoYoo Jin HongYoung Jin KimPurevjargal LkhagvasurenIksung ChoChi Young ShimJong-Won HaGeu-Ru HongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiwon Seo Yoo Jin Hong Young Jin Kim Purevjargal Lkhagvasuren Iksung Cho Chi Young Shim Jong-Won Ha Geu-Ru Hong Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
description	Abstract We sought to investigate the prevalence, functional characteristics, and clinical significance of right ventricular (RV) involvement in patients with hypertrophic cardiomyopathy (HCM). A total of 256 patients with HCM who underwent both cardiac magnetic resonance (CMR) imaging and transthoracic echocardiography within 6 months of each other were retrospectively analysed. RV involvement was defined as an increased RV wall thickness ≥ 7 mm on CMR in the segments of the RV free wall. Primary outcomes were defined as the composite of all-cause death, heart transplantation, and unplanned cardiovascular admission. Thirty-seven (14.4%) patients showed RV involvement. Patients with RV involvement showed a significantly higher left ventricular (LV) maximal wall thickness and left atrial volume index. Multivariate Cox model revealed that RV involvement was independently associated with primary outcomes (HR: 2.30, p = 0.024). In a subgroup analysis of patients with speckle tracking echocardiography (n = 190), those with RV involvement had significantly more impaired RV strain, which was independently associated with primary outcomes. RV involvement in patients with HCM correlated with more advanced LV structure and biventricular dysfunction, suggesting an indicator of severe HCM. RV involvement and impaired RV strain have a prognostic value related to clinical adverse events in patients with HCM.
format	article
author	Jiwon Seo Yoo Jin Hong Young Jin Kim Purevjargal Lkhagvasuren Iksung Cho Chi Young Shim Jong-Won Ha Geu-Ru Hong
author_facet	Jiwon Seo Yoo Jin Hong Young Jin Kim Purevjargal Lkhagvasuren Iksung Cho Chi Young Shim Jong-Won Ha Geu-Ru Hong
author_sort	Jiwon Seo
title	Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
title_short	Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
title_full	Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
title_fullStr	Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
title_full_unstemmed	Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
title_sort	prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1d7032b89add4539b28f40d0dfe6eaae
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Prevalence, functional characteristics, and clinical significance of right ventricular involvement in patients with hypertrophic cardiomyopathy

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