Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

Background: Factor V [Leiden] mutation, also known as activated protein-C resistance, is the most common of the inherited thrombophilias. Aim of the work: The present study aimed to ass the prevalence of factor V Leiden mutation in a group of Egyptian pregnant women and its relation to maternal and...

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Autores principales:	Ahmed Alsheikh, Ahmed Elsadek, Samy Gebreel
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	factor v leiden preeclampsia uterine artery doppler mutation egyptian Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1d74a8266c1f40488ddd360b348fcab1
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spelling	oai:doaj.org-article:1d74a8266c1f40488ddd360b348fcab12021-12-02T14:06:31ZPrevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women2636-41742682-378010.21608/ijma.2020.39091.1155https://doaj.org/article/1d74a8266c1f40488ddd360b348fcab12021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_121247_da55d2809d9256969fb1a4346b3f24b5.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Factor V [Leiden] mutation, also known as activated protein-C resistance, is the most common of the inherited thrombophilias. Aim of the work: The present study aimed to ass the prevalence of factor V Leiden mutation in a group of Egyptian pregnant women and its relation to maternal and neonatal outcomes. Patients and methods: The present prospective study included 130 preeclamptic women with a singleton pregnancy in the 3rd trimester. Blood samples were obtained for DNA analysis to assay factor V Leiden mutation. Transabdominal obstetric ultrasound examination was performed to confirm the fetal number, viability, presentation, estimated fetal weight, position & grade of the placenta, amount of liquor, biophysical profile, and gestational age. This was achieved through the measurements of the biparietal diameter, head circumference, abdominal circumference, and femur length. Flow velocity waveforms were obtained from each uterine artery. Results: Factor V Leiden [FVL] mutation was identified in 20 patients [15.4 %]. Comparison between women with FVL and women without revealed a significantly higher frequency of intrauterine growth restriction [IUGR], intrauterine fetal death [IUFD], small for gestational age [SGA], preterm labor, and intensive care unit [ICU] admission among women with FVL mutation. They also have a significantly higher frequency of abnormal Doppler findings, abruptio placenta, and placental infarction. Conclusion: The present study suggested that maternal and neonatal complications in PE patients may be related to FVL, abnormal uterine artery Doppler findings, and placental infarction.Ahmed AlsheikhAhmed ElsadekSamy GebreelAl-Azhar University, Faculty of Medicine (Damietta)articlefactor v leidenpreeclampsiauterine artery dopplermutationegyptianMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 1033-1038 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	factor v leiden preeclampsia uterine artery doppler mutation egyptian Medicine (General) R5-920
spellingShingle	factor v leiden preeclampsia uterine artery doppler mutation egyptian Medicine (General) R5-920 Ahmed Alsheikh Ahmed Elsadek Samy Gebreel Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women
description	Background: Factor V [Leiden] mutation, also known as activated protein-C resistance, is the most common of the inherited thrombophilias. Aim of the work: The present study aimed to ass the prevalence of factor V Leiden mutation in a group of Egyptian pregnant women and its relation to maternal and neonatal outcomes. Patients and methods: The present prospective study included 130 preeclamptic women with a singleton pregnancy in the 3rd trimester. Blood samples were obtained for DNA analysis to assay factor V Leiden mutation. Transabdominal obstetric ultrasound examination was performed to confirm the fetal number, viability, presentation, estimated fetal weight, position & grade of the placenta, amount of liquor, biophysical profile, and gestational age. This was achieved through the measurements of the biparietal diameter, head circumference, abdominal circumference, and femur length. Flow velocity waveforms were obtained from each uterine artery. Results: Factor V Leiden [FVL] mutation was identified in 20 patients [15.4 %]. Comparison between women with FVL and women without revealed a significantly higher frequency of intrauterine growth restriction [IUGR], intrauterine fetal death [IUFD], small for gestational age [SGA], preterm labor, and intensive care unit [ICU] admission among women with FVL mutation. They also have a significantly higher frequency of abnormal Doppler findings, abruptio placenta, and placental infarction. Conclusion: The present study suggested that maternal and neonatal complications in PE patients may be related to FVL, abnormal uterine artery Doppler findings, and placental infarction.
format	article
author	Ahmed Alsheikh Ahmed Elsadek Samy Gebreel
author_facet	Ahmed Alsheikh Ahmed Elsadek Samy Gebreel
author_sort	Ahmed Alsheikh
title	Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women
title_short	Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women
title_full	Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women
title_fullStr	Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women
title_full_unstemmed	Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women
title_sort	prevalence and clinical significance of factor v leiden mutation in egyptian preeclamptic women
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/1d74a8266c1f40488ddd360b348fcab1
work_keys_str_mv	AT ahmedalsheikh prevalenceandclinicalsignificanceoffactorvleidenmutationinegyptianpreeclampticwomen AT ahmedelsadek prevalenceandclinicalsignificanceoffactorvleidenmutationinegyptianpreeclampticwomen AT samygebreel prevalenceandclinicalsignificanceoffactorvleidenmutationinegyptianpreeclampticwomen
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Prevalence and Clinical Significance of Factor V Leiden Mutation in Egyptian Preeclamptic Women

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