Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.

Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal,...

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Autores principales:	Shin Teng, Chia-Feng Lu, Po-Shan Wang, Cheng-Ta Li, Pei-Chi Tu, Chih-I Hung, Tung-Ping Su, Yu-Te Wu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d7c0df60eb04e0b81cea38033eecd52
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spelling	oai:doaj.org-article:1d7c0df60eb04e0b81cea38033eecd522021-11-18T08:21:04ZAltered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.1932-620310.1371/journal.pone.0096422https://doaj.org/article/1d7c0df60eb04e0b81cea38033eecd522014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24788849/?tool=EBIhttps://doaj.org/toc/1932-6203Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy controls. Significantly decreased connectivity in the striatal-thalamic circuit and between the striatal regions and the middle and posterior cingulate cortex was observed in the bipolar patients. We also observed that the bipolar patients exhibited significantly increased connectivity between the thalamic regions and the parahippocampus. No significant changes of connectivity related to the frontal regions in the DMN were observed. The changed resting-state connectivity related to the striatal-thalamic circuit might be an inherent basis for the altered emotional and cognitive processing in the bipolar patients.Shin TengChia-Feng LuPo-Shan WangCheng-Ta LiPei-Chi TuChih-I HungTung-Ping SuYu-Te WuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 5, p e96422 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shin Teng Chia-Feng Lu Po-Shan Wang Cheng-Ta Li Pei-Chi Tu Chih-I Hung Tung-Ping Su Yu-Te Wu Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
description	Bipolar disorder is characterized by internally affective fluctuations. The abnormality of inherently mental state can be assessed using resting-state fMRI data without producing task-induced biases. In this study, we hypothesized that the resting-state connectivity related to the frontal, striatal, and thalamic regions, which were associated with mood regulations and cognitive functions, can be altered for bipolar disorder. We used the Pearson's correlation coefficients to estimate functional connectivity followed by the hierarchical modular analysis to categorize the resting-state functional regions of interest (ROIs). The selected functional connectivities associated with the striatal-thalamic circuit and default mode network (DMN) were compared between bipolar patients and healthy controls. Significantly decreased connectivity in the striatal-thalamic circuit and between the striatal regions and the middle and posterior cingulate cortex was observed in the bipolar patients. We also observed that the bipolar patients exhibited significantly increased connectivity between the thalamic regions and the parahippocampus. No significant changes of connectivity related to the frontal regions in the DMN were observed. The changed resting-state connectivity related to the striatal-thalamic circuit might be an inherent basis for the altered emotional and cognitive processing in the bipolar patients.
format	article
author	Shin Teng Chia-Feng Lu Po-Shan Wang Cheng-Ta Li Pei-Chi Tu Chih-I Hung Tung-Ping Su Yu-Te Wu
author_facet	Shin Teng Chia-Feng Lu Po-Shan Wang Cheng-Ta Li Pei-Chi Tu Chih-I Hung Tung-Ping Su Yu-Te Wu
author_sort	Shin Teng
title	Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
title_short	Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
title_full	Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
title_fullStr	Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
title_full_unstemmed	Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
title_sort	altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/1d7c0df60eb04e0b81cea38033eecd52
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Altered resting-state functional connectivity of striatal-thalamic circuit in bipolar disorder.

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