Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation

ATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation.

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Autores principales:	Hiroyuki Takatsu, Masahiro Takayama, Tomoki Naito, Naoto Takada, Kazuya Tsumagari, Yasushi Ishihama, Kazuhisa Nakayama, Hye-Won Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1d7e2d5697f84925aba45325575c3bb5
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spelling	oai:doaj.org-article:1d7e2d5697f84925aba45325575c3bb52021-12-02T14:42:06ZPhospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation10.1038/s41467-017-01338-12041-1723https://doaj.org/article/1d7e2d5697f84925aba45325575c3bb52017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01338-1https://doaj.org/toc/2041-1723ATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation.Hiroyuki TakatsuMasahiro TakayamaTomoki NaitoNaoto TakadaKazuya TsumagariYasushi IshihamaKazuhisa NakayamaHye-Won ShinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroyuki Takatsu Masahiro Takayama Tomoki Naito Naoto Takada Kazuya Tsumagari Yasushi Ishihama Kazuhisa Nakayama Hye-Won Shin Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
description	ATP11C is a flippase that uses ATP hydrolysis to translocate phospholipids at the plasma membrane. Here, the authors show that the activation of Ca2+-dependent protein kinase C increases ATP11C endocytosis thus downregulating phospholipid translocation.
format	article
author	Hiroyuki Takatsu Masahiro Takayama Tomoki Naito Naoto Takada Kazuya Tsumagari Yasushi Ishihama Kazuhisa Nakayama Hye-Won Shin
author_facet	Hiroyuki Takatsu Masahiro Takayama Tomoki Naito Naoto Takada Kazuya Tsumagari Yasushi Ishihama Kazuhisa Nakayama Hye-Won Shin
author_sort	Hiroyuki Takatsu
title	Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
title_short	Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
title_full	Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
title_fullStr	Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
title_full_unstemmed	Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation
title_sort	phospholipid flippase atp11c is endocytosed and downregulated following ca2+-mediated protein kinase c activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1d7e2d5697f84925aba45325575c3bb5
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_version_	1718389796252942336

Phospholipid flippase ATP11C is endocytosed and downregulated following Ca2+-mediated protein kinase C activation

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