Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, undersco...
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Nature Portfolio
2020
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oai:doaj.org-article:1d8037faca4e43bfbbf32bcfca139cb82021-12-02T16:04:25ZBone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis10.1038/s41467-020-16878-22041-1723https://doaj.org/article/1d8037faca4e43bfbbf32bcfca139cb82020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16878-2https://doaj.org/toc/2041-1723Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, underscoring BMAT’s potential to influence systemic glucose homeostasis.Karla J. SuchackiAdriana A. S. TavaresDomenico MattiucciErica L. SchellerGiorgos PapanastasiouCalum GrayMatthew C. SintonLynne E. RamageWendy A. McDougaldAndrea LovdelRichard J. SulstonBenjamin J. ThomasBonnie M. NicholsonAmanda J. DrakeCarlos J. Alcaide-CorralDiana SaidAntonella PoloniSaverio CintiGavin J. MacphersonMarc R. DweckJack P. M. AndrewsMichelle C. WilliamsRobert J. WallaceEdwin J. R. van BeekOrmond A. MacDougaldNicholas M. MortonRoland H. StimsonWilliam P. CawthornNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Karla J. Suchacki Adriana A. S. Tavares Domenico Mattiucci Erica L. Scheller Giorgos Papanastasiou Calum Gray Matthew C. Sinton Lynne E. Ramage Wendy A. McDougald Andrea Lovdel Richard J. Sulston Benjamin J. Thomas Bonnie M. Nicholson Amanda J. Drake Carlos J. Alcaide-Corral Diana Said Antonella Poloni Saverio Cinti Gavin J. Macpherson Marc R. Dweck Jack P. M. Andrews Michelle C. Williams Robert J. Wallace Edwin J. R. van Beek Ormond A. MacDougald Nicholas M. Morton Roland H. Stimson William P. Cawthorn Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| description |
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, underscoring BMAT’s potential to influence systemic glucose homeostasis. |
| format |
article |
| author |
Karla J. Suchacki Adriana A. S. Tavares Domenico Mattiucci Erica L. Scheller Giorgos Papanastasiou Calum Gray Matthew C. Sinton Lynne E. Ramage Wendy A. McDougald Andrea Lovdel Richard J. Sulston Benjamin J. Thomas Bonnie M. Nicholson Amanda J. Drake Carlos J. Alcaide-Corral Diana Said Antonella Poloni Saverio Cinti Gavin J. Macpherson Marc R. Dweck Jack P. M. Andrews Michelle C. Williams Robert J. Wallace Edwin J. R. van Beek Ormond A. MacDougald Nicholas M. Morton Roland H. Stimson William P. Cawthorn |
| author_facet |
Karla J. Suchacki Adriana A. S. Tavares Domenico Mattiucci Erica L. Scheller Giorgos Papanastasiou Calum Gray Matthew C. Sinton Lynne E. Ramage Wendy A. McDougald Andrea Lovdel Richard J. Sulston Benjamin J. Thomas Bonnie M. Nicholson Amanda J. Drake Carlos J. Alcaide-Corral Diana Said Antonella Poloni Saverio Cinti Gavin J. Macpherson Marc R. Dweck Jack P. M. Andrews Michelle C. Williams Robert J. Wallace Edwin J. R. van Beek Ormond A. MacDougald Nicholas M. Morton Roland H. Stimson William P. Cawthorn |
| author_sort |
Karla J. Suchacki |
| title |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_short |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_full |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_fullStr |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_full_unstemmed |
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| title_sort |
bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1d8037faca4e43bfbbf32bcfca139cb8 |
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