Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging

Abstract Many forms of lung disease manifest themselves as pathological changes in the transport of gas to the circulatory system, yet the difficulty of imaging this process remains a central obstacle to the comprehensive diagnosis of lung disorders. Using hyperpolarized xenon-129 as a surrogate mar...

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Autores principales:	Kai Ruppert, Hooman Hamedani, Faraz Amzajerdian, Yi Xin, Ian F. Duncan, Harrilla Profka, Sarmad Siddiqui, Mehrdad Pourfathi, Stephen Kadlecek, Rahim R. Rizi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1d80402b791342c1b5ba90467915e0ec
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spelling	oai:doaj.org-article:1d80402b791342c1b5ba90467915e0ec2021-12-02T15:08:53ZAssessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging10.1038/s41598-018-25713-02045-2322https://doaj.org/article/1d80402b791342c1b5ba90467915e0ec2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25713-0https://doaj.org/toc/2045-2322Abstract Many forms of lung disease manifest themselves as pathological changes in the transport of gas to the circulatory system, yet the difficulty of imaging this process remains a central obstacle to the comprehensive diagnosis of lung disorders. Using hyperpolarized xenon-129 as a surrogate marker for oxygen, we derived the temporal dynamics of gas transport from the ratio of two lung images obtained with different timing parameters. Additionally, by monitoring changes in the total hyperpolarized xenon signal intensity in the left side of the heart induced by depletion of xenon signal in the alveolar airspaces of interest, we quantified the contributions of selected lung volumes to the total pulmonary gas transport. In a rabbit model, we found that it takes at least 200 ms for xenon gas to enter the lung tissue and travel the distance from the airspaces to the heart. Additionally, our method shows that both lungs contribute fairly equally to the gas transport in healthy rabbits, but that this ratio changes in a rabbit model of acid aspiration. These results suggest that hyperpolarized xenon-129 MRI may improve our ability to measure pulmonary gas transport and detect associated pathological changes.Kai RuppertHooman HamedaniFaraz AmzajerdianYi XinIan F. DuncanHarrilla ProfkaSarmad SiddiquiMehrdad PourfathiStephen KadlecekRahim R. RiziNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Ruppert Hooman Hamedani Faraz Amzajerdian Yi Xin Ian F. Duncan Harrilla Profka Sarmad Siddiqui Mehrdad Pourfathi Stephen Kadlecek Rahim R. Rizi Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
description	Abstract Many forms of lung disease manifest themselves as pathological changes in the transport of gas to the circulatory system, yet the difficulty of imaging this process remains a central obstacle to the comprehensive diagnosis of lung disorders. Using hyperpolarized xenon-129 as a surrogate marker for oxygen, we derived the temporal dynamics of gas transport from the ratio of two lung images obtained with different timing parameters. Additionally, by monitoring changes in the total hyperpolarized xenon signal intensity in the left side of the heart induced by depletion of xenon signal in the alveolar airspaces of interest, we quantified the contributions of selected lung volumes to the total pulmonary gas transport. In a rabbit model, we found that it takes at least 200 ms for xenon gas to enter the lung tissue and travel the distance from the airspaces to the heart. Additionally, our method shows that both lungs contribute fairly equally to the gas transport in healthy rabbits, but that this ratio changes in a rabbit model of acid aspiration. These results suggest that hyperpolarized xenon-129 MRI may improve our ability to measure pulmonary gas transport and detect associated pathological changes.
format	article
author	Kai Ruppert Hooman Hamedani Faraz Amzajerdian Yi Xin Ian F. Duncan Harrilla Profka Sarmad Siddiqui Mehrdad Pourfathi Stephen Kadlecek Rahim R. Rizi
author_facet	Kai Ruppert Hooman Hamedani Faraz Amzajerdian Yi Xin Ian F. Duncan Harrilla Profka Sarmad Siddiqui Mehrdad Pourfathi Stephen Kadlecek Rahim R. Rizi
author_sort	Kai Ruppert
title	Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
title_short	Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
title_full	Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
title_fullStr	Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
title_full_unstemmed	Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
title_sort	assessment of pulmonary gas transport in rabbits using hyperpolarized xenon-129 magnetic resonance imaging
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1d80402b791342c1b5ba90467915e0ec
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Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging

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