Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese individuals lead to loss of SRC-1 function.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/1d82850af2594a8381d4f4b41b3524ec |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:1d82850af2594a8381d4f4b41b3524ec |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:1d82850af2594a8381d4f4b41b3524ec2021-12-02T14:39:18ZSteroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis10.1038/s41467-019-08737-62041-1723https://doaj.org/article/1d82850af2594a8381d4f4b41b3524ec2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08737-6https://doaj.org/toc/2041-1723Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese individuals lead to loss of SRC-1 function.Yongjie YangAgatha A. van der KlaauwLiangru ZhuTessa M. CacciottoloYanlin HeLukas K. J. StadlerChunmei WangPingwen XuKenji SaitoAntentor HintonXiaofeng YanJulia M. KeoghElana HenningMatthew C. BantonAudrey E. HendricksElena G. BochukovaVanisha MistryKatherine L. LawlerLan LiaoJianming XuStephen O’RahillyQingchun TongUK10K ConsortiumInês BarrosoBert W. O’MalleyI. Sadaf FarooqiYong XuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yongjie Yang Agatha A. van der Klaauw Liangru Zhu Tessa M. Cacciottolo Yanlin He Lukas K. J. Stadler Chunmei Wang Pingwen Xu Kenji Saito Antentor Hinton Xiaofeng Yan Julia M. Keogh Elana Henning Matthew C. Banton Audrey E. Hendricks Elena G. Bochukova Vanisha Mistry Katherine L. Lawler Lan Liao Jianming Xu Stephen O’Rahilly Qingchun Tong UK10K Consortium Inês Barroso Bert W. O’Malley I. Sadaf Farooqi Yong Xu Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis |
| description |
Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese individuals lead to loss of SRC-1 function. |
| format |
article |
| author |
Yongjie Yang Agatha A. van der Klaauw Liangru Zhu Tessa M. Cacciottolo Yanlin He Lukas K. J. Stadler Chunmei Wang Pingwen Xu Kenji Saito Antentor Hinton Xiaofeng Yan Julia M. Keogh Elana Henning Matthew C. Banton Audrey E. Hendricks Elena G. Bochukova Vanisha Mistry Katherine L. Lawler Lan Liao Jianming Xu Stephen O’Rahilly Qingchun Tong UK10K Consortium Inês Barroso Bert W. O’Malley I. Sadaf Farooqi Yong Xu |
| author_facet |
Yongjie Yang Agatha A. van der Klaauw Liangru Zhu Tessa M. Cacciottolo Yanlin He Lukas K. J. Stadler Chunmei Wang Pingwen Xu Kenji Saito Antentor Hinton Xiaofeng Yan Julia M. Keogh Elana Henning Matthew C. Banton Audrey E. Hendricks Elena G. Bochukova Vanisha Mistry Katherine L. Lawler Lan Liao Jianming Xu Stephen O’Rahilly Qingchun Tong UK10K Consortium Inês Barroso Bert W. O’Malley I. Sadaf Farooqi Yong Xu |
| author_sort |
Yongjie Yang |
| title |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis |
| title_short |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis |
| title_full |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis |
| title_fullStr |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis |
| title_full_unstemmed |
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis |
| title_sort |
steroid receptor coactivator-1 modulates the function of pomc neurons and energy homeostasis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/1d82850af2594a8381d4f4b41b3524ec |
| work_keys_str_mv |
AT yongjieyang steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT agathaavanderklaauw steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT liangruzhu steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT tessamcacciottolo steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT yanlinhe steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT lukaskjstadler steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT chunmeiwang steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT pingwenxu steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT kenjisaito steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT antentorhinton steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT xiaofengyan steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT juliamkeogh steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT elanahenning steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT matthewcbanton steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT audreyehendricks steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT elenagbochukova steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT vanishamistry steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT katherinellawler steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT lanliao steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT jianmingxu steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT stephenorahilly steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT qingchuntong steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT uk10kconsortium steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT inesbarroso steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT bertwomalley steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT isadaffarooqi steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis AT yongxu steroidreceptorcoactivator1modulatesthefunctionofpomcneuronsandenergyhomeostasis |
| _version_ |
1718390642481037312 |