The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology

Context The term inflammatory bowel disease (IBD) classically includes ulcerative colitis (UC) and Crohn’s disease (CD). An abnormally increased mucosal permeability seems to underlie UC, whereas CD is thought to be the result of an immune deficiency state. Evidence Acquisition While these phen...

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Autor principal:	Giovanni Clemente Actis
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2016
Materias:	inflammatory bowel disease physiopathology microbiome epidemiology genetics Medicine R
Acceso en línea:	https://doaj.org/article/1d87e1c8bff7416b88c66e022112faf6
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spelling	oai:doaj.org-article:1d87e1c8bff7416b88c66e022112faf62021-11-15T09:43:49ZThe Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology2783-243010.17795/acr-32942https://doaj.org/article/1d87e1c8bff7416b88c66e022112faf62016-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45506_710ded733ab92de7de6352d5509604bf.pdfhttps://doaj.org/toc/2783-2430Context The term inflammatory bowel disease (IBD) classically includes ulcerative colitis (UC) and Crohn’s disease (CD). An abnormally increased mucosal permeability seems to underlie UC, whereas CD is thought to be the result of an immune deficiency state. Evidence Acquisition While these phenomena may well be labeled as genetic factors, the environment has its role as well. Drugs (chiefly, antibiotics and non-steroidal anti-inflammatory molecules, with proton pump inhibitors recently joining the list) and smoking habits are all being scrutinized as IBD causative factors. Results Once almost unknown, the prevalence of IBD, in the Eastern World and China, is now increasing by manifold, therefore arousing warning signals. Conclusions A multidisciplinary approach will soon be necessary, to face the tenacious behavior of IBD, on a global perspective.Giovanni Clemente ActisShiraz University of Medical Sciencesarticleinflammatory bowel diseasephysiopathologymicrobiomeepidemiologygeneticsMedicineRENIranian Journal of Colorectal Research, Vol 4, Iss 1, Pp 0-0 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammatory bowel disease physiopathology microbiome epidemiology genetics Medicine R
spellingShingle	inflammatory bowel disease physiopathology microbiome epidemiology genetics Medicine R Giovanni Clemente Actis The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
description	Context The term inflammatory bowel disease (IBD) classically includes ulcerative colitis (UC) and Crohn’s disease (CD). An abnormally increased mucosal permeability seems to underlie UC, whereas CD is thought to be the result of an immune deficiency state. Evidence Acquisition While these phenomena may well be labeled as genetic factors, the environment has its role as well. Drugs (chiefly, antibiotics and non-steroidal anti-inflammatory molecules, with proton pump inhibitors recently joining the list) and smoking habits are all being scrutinized as IBD causative factors. Results Once almost unknown, the prevalence of IBD, in the Eastern World and China, is now increasing by manifold, therefore arousing warning signals. Conclusions A multidisciplinary approach will soon be necessary, to face the tenacious behavior of IBD, on a global perspective.
format	article
author	Giovanni Clemente Actis
author_facet	Giovanni Clemente Actis
author_sort	Giovanni Clemente Actis
title	The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
title_short	The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
title_full	The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
title_fullStr	The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
title_full_unstemmed	The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology
title_sort	changing face of inflammatory bowel disease: etiology, physiopathology, epidemiology
publisher	Shiraz University of Medical Sciences
publishDate	2016
url	https://doaj.org/article/1d87e1c8bff7416b88c66e022112faf6
work_keys_str_mv	AT giovanniclementeactis thechangingfaceofinflammatoryboweldiseaseetiologyphysiopathologyepidemiology AT giovanniclementeactis changingfaceofinflammatoryboweldiseaseetiologyphysiopathologyepidemiology
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The Changing Face of Inflammatory Bowel Disease: Etiology, Physiopathology, Epidemiology

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